Cost-Effectiveness of Intravascular Imaging-Guided Complex PCI: Prespecified Analysis of RENOVATE-COMPLEX-PCI Trial
DC Field | Value | Language |
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dc.contributor.author | Hong, David | - |
dc.contributor.author | Lee, Jin | - |
dc.contributor.author | Lee, Hankil | - |
dc.contributor.author | Cho, Juhee | - |
dc.contributor.author | Guallar, Eliseo | - |
dc.contributor.author | Choi, Ki Hong | - |
dc.contributor.author | Lee, Seung Hun | - |
dc.contributor.author | Shin, Doosup | - |
dc.contributor.author | Lee, Jong-Young | - |
dc.contributor.author | Lee, Seung-Jae | - |
dc.contributor.author | Lee, Sang Yeub | - |
dc.contributor.author | Kim, Sang Min | - |
dc.contributor.author | Yun, Kyeong Ho | - |
dc.contributor.author | Cho, Jae Young | - |
dc.contributor.author | Kim, Chan Joon | - |
dc.contributor.author | Ahn, Hyo-Suk | - |
dc.contributor.author | Nam, Chang-Wook | - |
dc.contributor.author | Yoon, Hyuck-Jun | - |
dc.contributor.author | Park, Yong Hwan | - |
dc.contributor.author | Lee, Wang Soo | - |
dc.contributor.author | Park, Taek Kyu | - |
dc.contributor.author | Yang, Jeong Hoon | - |
dc.contributor.author | Choi, Seung-Hyuk | - |
dc.contributor.author | Gwon, Hyeon-Cheol | - |
dc.contributor.author | Song, Young Bin | - |
dc.contributor.author | Hahn, Joo-Yong | - |
dc.contributor.author | Kang, Danbee | - |
dc.contributor.author | Lee, Joo Myung | - |
dc.date.accessioned | 2024-04-11T11:30:40Z | - |
dc.date.available | 2024-04-11T11:30:40Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 1941-7713 | - |
dc.identifier.issn | 1941-7705 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73161 | - |
dc.description.abstract | BACKGROUND: Although clinical benefits of intravascular imaging-guided percutaneous coronary intervention (PCI) in patients with complex coronary artery lesions have been observed in previous trials, the cost-effectiveness of this strategy is uncertain. METHODS: RENOVATE-COMPLEX-PCI (Randomized Controlled Trial of Intravascular Imaging Guidance vs Angiography-Guidance on Clinical Outcomes After Complex Percutaneous Coronary Intervention) was conducted in Korea between May 2018 and May 2021. This prespecified cost-effectiveness substudy was conducted using Markov model that simulated 3 states: (1) post-PCI, (2) spontaneous myocardial infarction, and (3) death. A simulated cohort was derived from the intention-to-treat population, and input parameters were extracted from either the trial data or previous publications. Cost-effectiveness was evaluated using time horizon of 3 years (within trial) and lifetime. The primary outcome was incremental cost-effectiveness ratio (ICER), an indicator of incremental cost on additional quality-adjusted life years (QALYs) gained, in intravascular imaging-guided PCI compared with angiography-guided PCI. The current analysis was performed using the Korean health care sector perspective with reporting the results in US dollar (1200 Korean Won, =1 dollar, $). Willingness to pay threshold was $35 000 per QALY gained. RESULTS: A total of 1639 patients were included in the trial. During 3-year follow-up, medical costs ($8661 versus $7236; incremental cost, $1426) and QALY (2.34 versus 2.31; incremental QALY, 0.025) were both higher in intravascular imaging-guided PCI than angiography-guided PCI, resulting incremental cost-effectiveness ratio of $57 040 per QALY gained within trial data. Conversely, lifetime simulation showed total cumulative medical cost was reversed between the 2 groups ($40 455 versus $49 519; incremental cost, -$9063) with consistently higher QALY (8.24 versus 7.89; incremental QALY, 0.910) in intravascular imaging-guided PCI than angiography-guided PCI, resulting in a dominant incremental cost-effectiveness ratio. Consistently, 70% of probabilistic iterations showed cost-effectiveness of intravascular imaging-guided PCI in probabilistic sensitivity analysis. CONCLUSIONS: The current cost-effectiveness analysis suggests that imaging-guided PCI is more cost-effective than angiography-guided PCI by reducing medical cost and increasing quality-of-life in complex coronary artery lesions in long-term follow-up. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03381872. © 2024 Lippincott Williams and Wilkins. All rights reserved. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams and Wilkins | - |
dc.title | Cost-Effectiveness of Intravascular Imaging-Guided Complex PCI: Prespecified Analysis of RENOVATE-COMPLEX-PCI Trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.1161/CIRCOUTCOMES.123.010230 | - |
dc.identifier.bibliographicCitation | Circulation: Cardiovascular Quality and Outcomes, v.17, no.3, pp 223 - 233 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001233669400004 | - |
dc.identifier.scopusid | 2-s2.0-85188117409 | - |
dc.citation.endPage | 233 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 223 | - |
dc.citation.title | Circulation: Cardiovascular Quality and Outcomes | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | coronary artery disease | - |
dc.subject.keywordAuthor | health care sector | - |
dc.subject.keywordAuthor | myocardial infarction | - |
dc.subject.keywordAuthor | percutaneous coronary intervention | - |
dc.subject.keywordAuthor | quality of life | - |
dc.subject.keywordPlus | OPTICAL COHERENCE TOMOGRAPHY | - |
dc.subject.keywordPlus | ELUTING STENT IMPLANTATION | - |
dc.subject.keywordPlus | DUAL ANTIPLATELET THERAPY | - |
dc.subject.keywordPlus | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject.keywordPlus | ANGIOGRAPHIC GUIDANCE | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | ULTRASOUND GUIDANCE | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | AMERICAN-COLLEGE | - |
dc.subject.keywordPlus | ARTERY-DISEASE | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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