The impact of sinusitis on the long-term clinical outcomes of asthma
DC Field | Value | Language |
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dc.contributor.author | Kim, Min-Hye | - |
dc.contributor.author | Jung, Jae-Woo | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.contributor.author | Min, Kyung-Up | - |
dc.contributor.author | Kang, Hye-Ryun | - |
dc.date.accessioned | 2024-04-13T01:30:27Z | - |
dc.date.available | 2024-04-13T01:30:27Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 2233-8276 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73223 | - |
dc.description.abstract | BACKGROUND: Upper respiratory diseases have been linked with lower respiratory diseases. However, the long-term effect of sinusitis on the clinical outcomes of asthma has not been fully evaluated. OBJECTIVE: The aim of this study was to investigate the impact of sinusitis on the disease progression of asthma. METHODS: Seventy-five asthmatic patients confirmed with the methacholine bronchial provocation test or bronchodilator response were included. The study patients underwent paranasal sinus x-ray upon their asthma evaluation and they visited the hospital at least 3 years or longer. We retrospectively reviewed their medical records and compared data according to the presence of comorbid sinusitis. RESULTS: Among the 75 asthmatic subjects, 38 subjects (50.7%) had radiologic evidence of sinusitis. Asthmatics with sinusitis had significantly lower forced expiratory volume in 1 second (FEV1; 79.2% vs. 88.2%) and PC20 values (5.2 mg/mL vs. 8.9 mg/mL) compared to asthmatics without sinusitis at the time of diagnosis. This difference in FEV1 disappeared (82.6% vs. 87.2%) in the 3-year follow-up, although FEV1 was more variable (31.7% vs. 23.5%) and worst FEV1 was also significantly lower in patients with sinusitis compared to those without (70.9% vs. 79.0%). There were no significant differences in the number of hospital visits, acute exacerbations, and scores for the asthma control test. CONCLUSIONS: Although sinusitis was associated with lower baseline lung function and higher hyperreactivity, sinusitis was not related with significant deterioration in lung function over 3 years of follow-up. Asthmatics with sinusitis showed more variability in lung function during the follow-up period. Healthcare utilization was not different except antibiotics use. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology | - |
dc.title | The impact of sinusitis on the long-term clinical outcomes of asthma | - |
dc.type | Article | - |
dc.identifier.doi | 10.5415/apallergy.2014.4.4.222 | - |
dc.identifier.bibliographicCitation | Asia Pacific allergy, v.4, no.4, pp 222 - 229 | - |
dc.description.isOpenAccess | Y | - |
dc.citation.endPage | 229 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 222 | - |
dc.citation.title | Asia Pacific allergy | - |
dc.citation.volume | 4 | - |
dc.type.docType | Journal Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | Disease progression | - |
dc.subject.keywordAuthor | Forced expiratory volume | - |
dc.subject.keywordAuthor | Sinusitis | - |
dc.description.journalRegisteredClass | domestic | - |
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