Effect of Mixture of Recombinant Human Bone Morphogenic Protein-2 and demineralized Bone Matrix in Lateral Lumbar Interbody Fusion
DC Field | Value | Language |
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dc.contributor.author | Son, Jun Ik | - |
dc.contributor.author | Lee, Young-Seok | - |
dc.contributor.author | Ko, Myeong Jin | - |
dc.contributor.author | Wui, Seong Hyun | - |
dc.contributor.author | Park, Seung Won | - |
dc.date.accessioned | 2024-04-13T03:00:33Z | - |
dc.date.available | 2024-04-13T03:00:33Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 2005-3711 | - |
dc.identifier.issn | 1598-7876 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73240 | - |
dc.description.abstract | This study aims to determine the optimal dose of recombinant-human Bone Morphogenic Protein-2 (rhBMP-2) for successful bone fusion in minimally invasive Lateral Lumbar Interbody Fusion (MIS LLIF). Previous studies show that rh-BMP is an effective alternative to autologous iliac crest bone graft, but the optimal dose remains uncertain. The study analyzes the fusion rates associated with different rh-BMP doses to provide a recommendation for the optimal dose in MIS LLIF. 93 patients underwent MIS LLIF using demineralized bone matrix (DBM) or a mixture of rhBMP-2 and DBM as fusion material. The group was divided into the following three groups according to the rhBMP-2 usage. Group A (only DBM was used, n: 27). Group B (1mg of rhBMP-2 per 5cc of DBM paste, n: 41). Group C (2mg of rhBMP-2 per 5cc of DBM paste, n: 25). Demographic data, clinical outcomes, postoperative complication and fusion were assessed. At 12 months post-surgery, the overall fusion rate was 92.3% according to Bridwell fusion grading system. Group B and C, who received rhBMP-2, had significantly higher fusion rates than group A, who received only DBM. However, there was no significant increase in fusion rate when the rhBMP-2 dosage was increased from group B to group C. The group B and C showed significant improvement in back pain and ODI compared to the group A. The incidence of screw loosening was decreased in group B and C, but there was no significant difference in the occurrence of other complications. Usage of rhBMP-2 in LLIF surgery leads to early and increased final fusion rates, which can result in faster pain relief and return to daily activities for patients. The benefits of using rhBMP-2 were not significantly different between the groups that received 1mg/5cc and 2mg/5cc of rhBMP-2. Therefore, it is recommended to use 1mg of rhBMP-2 with 5cc of DBM, taking both economic and clinical aspects into consideration. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한신경외과학회 | - |
dc.title | Effect of Mixture of Recombinant Human Bone Morphogenic Protein-2 and demineralized Bone Matrix in Lateral Lumbar Interbody Fusion | - |
dc.type | Article | - |
dc.identifier.doi | 10.3340/jkns.2023.0136 | - |
dc.identifier.bibliographicCitation | Journal of Korean Neurosurgical Society, v.67, no.3, pp 354 - 363 | - |
dc.identifier.kciid | ART003076287 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001222862600002 | - |
dc.identifier.scopusid | 2-s2.0-85194280227 | - |
dc.citation.endPage | 363 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 354 | - |
dc.citation.title | Journal of Korean Neurosurgical Society | - |
dc.citation.volume | 67 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Bone morphogenetic protein 2 | - |
dc.subject.keywordAuthor | Demineralized bone matrix | - |
dc.subject.keywordAuthor | Spinal fusion | - |
dc.subject.keywordPlus | DEGENERATIVE DISEASE | - |
dc.subject.keywordPlus | GUIDELINE UPDATE | - |
dc.subject.keywordPlus | RHBMP-2 | - |
dc.subject.keywordPlus | GRAFT | - |
dc.subject.keywordPlus | LAMINECTOMY | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | ALLOGRAFT | - |
dc.subject.keywordPlus | MOTION | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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