Profiling the Phytochemicals of <i>Orostachys margaritifolia</i>: Biological Activities, LC-ESI/MS, and HPLC Analyses
DC Field | Value | Language |
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dc.contributor.author | Yoon, Nari | - |
dc.contributor.author | Yu, Hyeonjun | - |
dc.contributor.author | Tran, Gia Han | - |
dc.contributor.author | Ko, Chung Ho | - |
dc.contributor.author | Kim, Hoon | - |
dc.contributor.author | Yoon, Mi Jeong | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.date.accessioned | 2024-04-19T06:30:49Z | - |
dc.date.available | 2024-04-19T06:30:49Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 1424-8247 | - |
dc.identifier.issn | 1424-8247 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73349 | - |
dc.description.abstract | Orostachys margaritifolia Y. N. Lee (OMY) is an endemic Korean plant in the family Crassulaceae that is known to contain a variety of bioactive compounds. To assess the physiological activities of an OMY ethanol extract, ABTS+ and DPPH radical scavenging assays and a nitric oxide (NO) inhibition assay were conducted. The phytochemical makeup of the extract was profiled via liquid chromatography-mass spectrometry (LC-ESI/MS) and high-performance liquid chromatography with a photodiode array detector (HPLC/PDA). The OMY extract was found to have weaker ABTS+ and DPPH radical scavenging activities than the control group (green tea). In the NO inhibition assay, the OMY extract induced a significant increase in macrophage cell viability but showed a lower NO inhibitory activity than l-NAME, producing an IC50 value of 202.6 mu g/mL. The LC-ESI/MS and HPLC/PDA analyses identified isoquercitrin and astragalin in the OMY extract, quantifying their contents at 3.74 mg/g and 3.19 mg/g, respectively. The study revealed possibilities for the utilization of OMY as a future source of drugs for alleviating inflammation and diseases related to reactive oxygen species. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Profiling the Phytochemicals of <i>Orostachys margaritifolia</i>: Biological Activities, LC-ESI/MS, and HPLC Analyses | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ph17030290 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICALS, v.17, no.3 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001193461600001 | - |
dc.identifier.scopusid | 2-s2.0-85188968582 | - |
dc.citation.number | 3 | - |
dc.citation.title | PHARMACEUTICALS | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | ABTS(+)-DPPH radical scavenging activity | - |
dc.subject.keywordAuthor | HPLC/PDA | - |
dc.subject.keywordAuthor | LC-ESI/MS | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | Orostachys margaritifolia | - |
dc.subject.keywordPlus | JAPONICUS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | ISOQUERCITRIN | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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