A narrative review of scar formation

Abstract

A scar is formed through a process in which the damaged skin, including the epidermis and dermis, is filled with abnormal connective tissue because of an imbalance in the response during the wound-healing process. This review investigates the process of normal wound healing, the molecular and biochemical changes during the process of scar formation, and various factors involved in the formation of scars. Scar formation is influenced by both internal and external factors which are associated with individual characteristics. It is important to have a clear understanding about these factors as they can be possible targets in the development of various scar prevention or treatment options. Also, some of them, especially some of the external factors, are preventable.