Dietary supplementation with Lacticaseibacillus rhamnosus IDCC3201 alleviates sarcopenia by modulating the gut microbiota and metabolites in dexamethasone-induced models
DC Field | Value | Language |
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dc.contributor.author | Kang, Minkyoung | - |
dc.contributor.author | Kang, Minji | - |
dc.contributor.author | Yoo, Jiseon | - |
dc.contributor.author | Lee, Juyeon | - |
dc.contributor.author | Lee, Sujeong | - |
dc.contributor.author | Yun, Bohyun | - |
dc.contributor.author | Song, Minho | - |
dc.contributor.author | Kim, Jun-Mo | - |
dc.contributor.author | Kim, Hyung Wook | - |
dc.contributor.author | Yang, Jungwoo | - |
dc.contributor.author | Kim, Younghoon | - |
dc.contributor.author | Oh, Sangnam | - |
dc.date.accessioned | 2024-04-24T08:00:30Z | - |
dc.date.available | 2024-04-24T08:00:30Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 2042-650X | - |
dc.identifier.issn | 2042-6496 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73460 | - |
dc.description.abstract | Probiotics can exert direct or indirect influences on various aspects of health claims by altering the composition of the gut microbiome and producing bioactive metabolites. The aim of this study was to examine the effect of Lacticaseibacillus rhamnosus IDCC3201 on skeletal muscle atrophy in dexamethasone-induced C2C12 cells and a mouse animal model. Dexamethasone treatment significantly reduced C2C12 muscle cell viability, myotube diameter, and levels of muscle atrophic markers (Atrogin-1 and MuRF-1). These effects were alleviated by conditioned media (CM) and cell extract (EX) derived from L. rhamnosus IDCC3201. In addition, we assessed the in vivo therapeutic effect of L. rhamnosus IDCC3201 in a mouse model of dexamethasone (DEX)-induced muscle atrophy. Supplementation with IDCC3201 resulted in significant enhancements in body composition, particularly in lean mass, muscle strength, and myofibril size, in DEX-induced muscle atrophy mice. In comparison to the DEX-treatment group, the normal and DEX + L. rhamnosus IDCC3201 groups showed a higher transcriptional level of myosin heavy chain family genes (MHC1, MHC1b, MHC2A, 2bB, and 2X) and a reduction in atrophic muscle makers. These analyses revealed that L. rhamnosus IDCC3201 supplementation led to increased production of branched-chain amino acids (BCAAs) and improved the Allobaculum genus within the gut microbiota of muscle atrophy-induced groups. Taken together, our findings suggest that L. rhamnosus IDCC3201 represents a promising dietary supplement with the potential to alleviate sarcopenia by modulating the gut microbiome and metabolites. | - |
dc.format.extent | 18 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Dietary supplementation with Lacticaseibacillus rhamnosus IDCC3201 alleviates sarcopenia by modulating the gut microbiota and metabolites in dexamethasone-induced models | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/d3fo05420a | - |
dc.identifier.bibliographicCitation | Food & function, v.15, no.9, pp 4936 - 4953 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001199925600001 | - |
dc.identifier.scopusid | 2-s2.0-85190360948 | - |
dc.citation.endPage | 4953 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 4936 | - |
dc.citation.title | Food & function | - |
dc.citation.volume | 15 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | EXOPOLYSACCHARIDES | - |
dc.subject.keywordPlus | PROBIOTICS | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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