Inhibition of reactive oxygen species generation by N-Acetyl Cysteine can mitigate male germ cell toxicity induced by bisphenol analogs
DC Field | Value | Language |
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dc.contributor.author | Kim, Seul Gi | - |
dc.contributor.author | Jeon, Jeong Hoon | - |
dc.contributor.author | Shin, Seung Hee | - |
dc.contributor.author | Varias, Daniel Chavez | - |
dc.contributor.author | Moon, Sung-Hwan | - |
dc.contributor.author | Ryu, Buom-Yong | - |
dc.date.accessioned | 2024-04-24T08:00:37Z | - |
dc.date.available | 2024-04-24T08:00:37Z | - |
dc.date.issued | 2024-06 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.issn | 1873-6351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73464 | - |
dc.description.abstract | The estrogen-like effect of bisphenol A (BPA) disrupting the maintenance of functional male germ cells is associated with male sub-fertility. This study investigated toxicity of male germ cells induced by four bisphenol analogs: BPA, BPAF, BPF, and BPS. The investigation of bisphenol analogs' impact on male germ cells included assessing proliferation, apoptosis induction, and the capacity to generate reactive oxygen species (ROS) in GC-1 spermatogonia (spg) cells, specifically type B spermatogonia. Additionally, the therapeutic potential and protective effects of N-Acetyl Cysteine (NAC) and NF-κB inhibitor parthenolide was evaluated. In comparison to BPA, BPF and BPS, BPAF exhibited the most pronounced adverse effect in GC-1 spg cell proliferation. This effect was characterized by pronounced inhibition of phosphorylation of PI3K, AKT, and mTOR, along with increased release of cytochrome c and subsequent cleavages of caspase 3, caspase 7, and poly (ADP-ribose) polymerase. Both NAC and parthenolide were effective reducing cellular ROS induced by BPAF. However, only NAC demonstrated a substantial recovery in proliferation, accompanied by a significant reduction in cytochrome c release and cleaved PARP. These results suggest that NAC supplementation may play an effective therapeutic role in countering germ cell toxicity induced by environmental pollutants with robust oxidative stress-generating capacity. Copyright © 2024. Published by Elsevier Ltd. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Inhibition of reactive oxygen species generation by N-Acetyl Cysteine can mitigate male germ cell toxicity induced by bisphenol analogs | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fct.2024.114652 | - |
dc.identifier.bibliographicCitation | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, v.188 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001230246300001 | - |
dc.identifier.scopusid | 2-s2.0-85190354392 | - |
dc.citation.title | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association | - |
dc.citation.volume | 188 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Bisphenol A | - |
dc.subject.keywordAuthor | Bisphenol AF | - |
dc.subject.keywordAuthor | Bisphenol F | - |
dc.subject.keywordAuthor | Bisphenol S | - |
dc.subject.keywordAuthor | Male germ cell toxicity | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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