Factors affecting long-term survival after surgical resection of pancreatic ductal adenocarcinomaopen access
- Authors
- Yoon, Kyoung Won; Heo, Jin Seok; Choi, Dong Wook; Choi, Seoung Ho
- Issue Date
- Dec-2011
- Publisher
- KOREAN SURGICAL SOCIETY
- Keywords
- Pancreatic neoplasms; Bilirubin; CA19-9 antigen
- Citation
- JOURNAL OF THE KOREAN SURGICAL SOCIETY, v.81, no.6, pp 394 - 401
- Pages
- 8
- Journal Title
- JOURNAL OF THE KOREAN SURGICAL SOCIETY
- Volume
- 81
- Number
- 6
- Start Page
- 394
- End Page
- 401
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73532
- DOI
- 10.4174/jkss.2011.81.6.394
- ISSN
- 2233-7903
- Abstract
- Purpose: Some patients who undergo surgical resection of pancreatic cancer survive longer than other patients. The purpose of this study was to identify the factors that affect long-term survival after resection of histopathologically confirmed pancreatic ductal adenocarcinoma. Methods: A single-center, retrospective study was conducted among 164 patients who underwent surgical resection of pancreatic cancer, between May 1995 and December 2004. The patient follow-up process was conducted via telephone survey and review of electronic medical records for at least 5 years or until death. Results: We compared patients with long-term (>= 60 months, n = 19) and short-term survival (<60 months, n = 145). Resection margin status, differentiation of the tumor, tumor stage, pre-operative serum level of albumin, total bilirubin and carbohydrate antigen (CA) 19-9 level are related with survival difference (all factors, P < 0.05). Multivariate analysis revealed that a pre-operative serum total bilirubin level <7 mg/dL and a pre-operative serum CA19-9 level <37 U/mL is a statistically significant prognostic factor for long-term survival. Conclusion: The preoperative serum total bilirubin and serum CA19-9 levels are associated with long-term survival after surgical resection of pancreatic cancer.
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