Targeting Src and Tubulin in Mucinous Ovarian Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Liu, Tao | - |
dc.contributor.author | Hu, Wei | - |
dc.contributor.author | Dalton, Heather J. | - |
dc.contributor.author | Choi, Hyun Jin | - |
dc.contributor.author | Huang, Jie | - |
dc.contributor.author | Kang, Yu | - |
dc.contributor.author | Pradeep, Sunila | - |
dc.contributor.author | Miyake, Takahito | - |
dc.contributor.author | Song, Jian H. | - |
dc.contributor.author | Wen, Yunfei | - |
dc.contributor.author | Lu, Chunhua | - |
dc.contributor.author | Pecot, Chad V. | - |
dc.contributor.author | Bottsford-Miller, Justin | - |
dc.contributor.author | Zand, Behrouz | - |
dc.contributor.author | Jennings, Nicholas B. | - |
dc.contributor.author | Ivan, Cristina | - |
dc.contributor.author | Gallick, Gary E. | - |
dc.contributor.author | Baggerly, Keith A. | - |
dc.contributor.author | Hangauer, David G. | - |
dc.contributor.author | Coleman, Robert L. | - |
dc.contributor.author | Frumovitz, Michael | - |
dc.contributor.author | Sood, Anil K. | - |
dc.date.accessioned | 2024-05-17T06:00:22Z | - |
dc.date.available | 2024-05-17T06:00:22Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.issn | 1557-3265 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73743 | - |
dc.description.abstract | Purpose: To investigate the antitumor effects of targeting Src and tubulin in mucinous ovarian carcinoma. Experimental Design: The in vitro and in vivo effects and molecular mechanisms of KX-01, which inhibits Src pathway and tubulin polymerization, were examined in mucinous ovarian cancer models. Results: In vitro studies using RMUG-S and RMUG-L cell lines showed that KX-01 inhibited cell proliferation, induced apoptosis, arrested the cell cycle at the G(2)-M phase, and enhanced the cytotoxicity of oxaliplatin in the KX-01-sensitive cell line, RMUG-S. In vivo studies showed that KX-01 significantly decreased tumor burden in RMUG-S and RMUG-L mouse models relative to untreated controls, and the effects were greater when KX-01 was combined with oxaliplatin. KX-01 alone and in combination with oxaliplatin significantly inhibited tumor growth by reducing cell proliferation and inducing apoptosis in vivo. PTEN knock-in experiments in RMUG-L cells showed improved response to KX-01. Reverse phase protein array analysis showed that in addition to blocking downstream molecules of Src family kinases, KX-01 also activated acute stress-inducing molecules. Conclusion: Our results showed that targeting both the Src pathway and tubulin with KX-01 significantly inhibited tumor growth in preclinical mucinous ovarian cancer models, suggesting that this may be a promising therapeutic approach for patients with mucinous ovarian carcinoma. Clin Cancer Res; 19( 23); 6532-43. (C) 2013 AACR. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.title | Targeting Src and Tubulin in Mucinous Ovarian Carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1158/1078-0432.CCR-13-1305 | - |
dc.identifier.bibliographicCitation | CLINICAL CANCER RESEARCH, v.19, no.23, pp 6532 - 6543 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000327819700022 | - |
dc.identifier.scopusid | 2-s2.0-84890288888 | - |
dc.citation.endPage | 6543 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 6532 | - |
dc.citation.title | CLINICAL CANCER RESEARCH | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | FAMILY KINASE INHIBITOR | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | PTEN | - |
dc.subject.keywordPlus | CDK1 | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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