Inhibitory Effects of Standardized Boesenbergia pandurata Extract and Its Active Compound Panduratin A on Lipopolysaccharide-Induced Periodontal Inflammation and Alveolar Bone Loss in Rats
DC Field | Value | Language |
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dc.contributor.author | Kim, Haebom | - |
dc.contributor.author | Kim, Changhee | - |
dc.contributor.author | Kook, Kyo Eun | - |
dc.contributor.author | Yanti | - |
dc.contributor.author | Choi, Seungmok | - |
dc.contributor.author | Kang, Wonku | - |
dc.contributor.author | Hwang, Jae-Kwan | - |
dc.date.available | 2019-01-22T12:37:44Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.issn | 1557-7600 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/737 | - |
dc.description.abstract | Periodontitis, an inflammatory disease of the gingival tissue, triggered by microbial-derived elements, such as lipopolysaccharide (LPS), collapses the periodontal tissues and resorbs the alveolar bone. This study evaluated the inhibitory effects of standardized Boesenbergia pandurata extract (BPE) and panduratin A (PAN) on periodontitis-induced inflammation and alveolar bone loss. Sprague-Dawley rats with LPS-induced periodontitis were orally administered BPE (50 and 200mg/kg/day) and PAN (20mg/kg/day) for 8 days. Histological analysis revealed that BPE- and PAN-administered groups showed decreased cell infiltration and alveolar bone resorption. Furthermore, the BPE and PAN significantly alleviated the mRNA and protein expression levels of nuclear factor kappa B (NF-B), interleukin-1, matrix metalloproteinase (MMP)-2, and MMP-8. BPE and PAN also inhibited the expression of nuclear factor of activated T cells, cytoplasmic 1, c-Fos, and ostoclastogenesis-related enzymes, including cathepsin K and tartrate-resistant acid phosphatase (ALP). BPE and PAN not only upregulated the osteoblastogenesis-associated markers, such as collagen type I (COL1A1) and ALP, but also increased the ratio of osteoprotegerin to receptor activator of NF-B ligand. Collectively, BPE and PAN efficiently prevent destruction of periodontal tissues and stimulating the loss of alveolar bone tissues, strongly indicative of their potential as natural antiperiodontitis agents. | - |
dc.format.extent | 10 | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.title | Inhibitory Effects of Standardized Boesenbergia pandurata Extract and Its Active Compound Panduratin A on Lipopolysaccharide-Induced Periodontal Inflammation and Alveolar Bone Loss in Rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.1089/jmf.2017.4155 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.21, no.10, pp 961 - 970 | - |
dc.identifier.kciid | ART002400756 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000447611200002 | - |
dc.identifier.scopusid | 2-s2.0-85055072740 | - |
dc.citation.endPage | 970 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 961 | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 21 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | alveolar bone | - |
dc.subject.keywordAuthor | Boesenbergia pandurata Roxb. | - |
dc.subject.keywordAuthor | gingival tissue | - |
dc.subject.keywordAuthor | panduratin A | - |
dc.subject.keywordAuthor | periodontitis | - |
dc.subject.keywordPlus | LIGAND-INDUCED OSTEOCLASTOGENESIS | - |
dc.subject.keywordPlus | RECEPTOR ACTIVATOR | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | NFATC1 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | HEALTHY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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