Clinical Characteristics and Radiologic Features of Immunocompromised Patients With Pauci-Bacillary Pulmonary Tuberculosis Receiving Delayed Diagnosis and Treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Joung Ha | - |
dc.contributor.author | Choe, Jooae | - |
dc.contributor.author | Bae, Moonsuk | - |
dc.contributor.author | Choi, Sungim | - |
dc.contributor.author | Jung, Kyung Hwa | - |
dc.contributor.author | Kim, Min Jae | - |
dc.contributor.author | Chong, Yong Pil | - |
dc.contributor.author | Lee, Sang-Oh | - |
dc.contributor.author | Choi, Sang-Ho | - |
dc.contributor.author | Kim, Yang Soo | - |
dc.contributor.author | Woo, Jun Hee | - |
dc.contributor.author | Jo, Kyung-Wook | - |
dc.contributor.author | Shim, Tae Sun | - |
dc.contributor.author | Kim, Mi Young | - |
dc.contributor.author | Kim, Sung-Han | - |
dc.date.accessioned | 2024-05-31T05:00:32Z | - |
dc.date.available | 2024-05-31T05:00:32Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 2328-8957 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73972 | - |
dc.description.abstract | Background. Pauci-bacillary pulmonary tuberculosis (TB) can be delayed to diagnose and start anti-TB therapy, especially in immunocompromised patients. We therefore evaluated the clinical and radiologic features of these delayed cases. Methods. Immunocompromised adult patients with pauci-bacillary pulmonary TB were retrospectively enrolled in a tertiary hospital in an intermediate-TB burden country over a 5-year period. We defined "missed TB" or "not-missed TB" patients as those who started anti-TB therapy after or before positive mycobacterial culture results, respectively. Results. Of 258 patients, 134 (52%) were classified in the missed TB group, and 124 (48%) in the not-missed TB group. Positive results of molecular tests including MTB polymerase chain reaction and/or Xpert TB/RIF were only obtained in the not-missed TB group (54/106, 54%). The median diagnostic delay in the missed TB group was longer than in the other group (30 vs 6 days; P < .001). In the missed TB group, the most common working diagnoses were pneumonia (46, 34%) and lung metastasis of malignancy (40, 30%). Typical radiologic findings for TB, such as upper lobe predominance and centrilobular nodules with tree-in-bud appearance, were less common in the missed TB group than in the other group. Old age (odds ratio [OR], 1.03), solid organ transplant (OR, 3.46), solid tumor (OR, 3.83), and hematologic malignancy (OR, 4.04) were independently associated with missed TB. Conclusions. Care is needed to differentiate pauci-bacillary TB, especially in immunocompromised patients with the mentioned risk factors, even without the usual radiologic features of TB. Additional rapid diagnostic tests to rule out pauci-bacillary TB are urgently needed. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Clinical Characteristics and Radiologic Features of Immunocompromised Patients With Pauci-Bacillary Pulmonary Tuberculosis Receiving Delayed Diagnosis and Treatment | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/ofid/ofz002 | - |
dc.identifier.bibliographicCitation | OPEN FORUM INFECTIOUS DISEASES, v.6, no.2 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000461522500005 | - |
dc.identifier.scopusid | 2-s2.0-85066489132 | - |
dc.citation.number | 2 | - |
dc.citation.title | OPEN FORUM INFECTIOUS DISEASES | - |
dc.citation.volume | 6 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | immunocompromised | - |
dc.subject.keywordAuthor | pauci-bacillary | - |
dc.subject.keywordAuthor | tuberculosis | - |
dc.subject.keywordPlus | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject.keywordPlus | MANIFESTATIONS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | IMPACT | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.