Clinical outcomes of adjusted-dose versus standard-dose prasugrel in East Asian patients with acute myocardial infarction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Honda, Satoshi | - |
dc.contributor.author | Lee, Sangyeub | - |
dc.contributor.author | Cho, Kyung Hoon | - |
dc.contributor.author | Takegami, Misa | - |
dc.contributor.author | Nishihira, Kensaku | - |
dc.contributor.author | Kojima, Sunao | - |
dc.contributor.author | Asaumi, Yasuhide | - |
dc.contributor.author | Saji, Mike | - |
dc.contributor.author | Yamashita, Jun | - |
dc.contributor.author | Hibi, Kiyoshi | - |
dc.contributor.author | Takahashi, Jun | - |
dc.contributor.author | Sakata, Yasuhiko | - |
dc.contributor.author | Takayama, Morimasa | - |
dc.contributor.author | Sumiyoshi, Tetsuya | - |
dc.contributor.author | Ogawa, Hisao | - |
dc.contributor.author | Kimura, Kazuo | - |
dc.contributor.author | Sim, Doo Sun | - |
dc.contributor.author | Kim, Hyun Kuk | - |
dc.contributor.author | Kim, Weon | - |
dc.contributor.author | Ahn, Youngkeun | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | Yasuda, Satoshi | - |
dc.date.accessioned | 2024-06-10T02:00:30Z | - |
dc.date.available | 2024-06-10T02:00:30Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.issn | 1874-1754 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74079 | - |
dc.description.abstract | Background:The comparative efficacy and safety of adjusted- and standard-dose prasugrel in East Asian patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) remain unclear. This study aimed to comparatively assess the ischaemic and bleeding outcomes of adjusted-dose (maintenance dose: 3.75 mg) and standard-dose (maintenance dose: 10 mg) prasugrel in East Asian patients with AMI undergoing PCI. Methods:From a combined dataset sourced from nationwide AMI registries in Japan and South Korea (n = 17,118), patients treated with either adjusted- or standard-dose prasugrel were identified. Patients who did not undergo emergent PCI, those on oral anticoagulants, and those meeting the criteria of contraindication of prasugrel in South Korea (age ≥ 75 years, body weight < 60 kg, or history of stroke) were excluded. Major adverse cardiovascular events (MACE) and Thrombolysis in Myocardial Infarction (TIMI) major bleeding events were compared between the adjusted-dose (n = 1160) and standard-dose (n = 1086) prasugrel groups.Results:Within the propensity-matched cohort (n = 702 in each group), no significant difference was observed in the in-hospital MACE between the adjusted- and standard-dose prasugrel groups (1.85% vs. 2.71%, odds ratio [OR] 0.68, 95% confidence interval [CI] 0.33–1.38, p = 0.286). However, the incidence of in-hospital major bleeding was significantly lower in the adjusted-dose prasugrel group than in the standard-dose group (0.43% vs. 1.71%, OR 0.25, 95% CI 0.07–0.88, p = 0.031). The cumulative 12-month incidence of MACE was equivalent in both groups (4.70% vs. 4.70%, OR 1.00, 95% CI 0.61–1.64, p = 1.000).Conclusions:Among East Asian patients with AMI undergoing PCI, those administered adjusted-dose prasugrel exhibited a lower risk of in-hospital bleeding events than those administered standard-dose prasugrel, while maintaining a comparable 1-year incidence of MAC | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ireland Ltd | - |
dc.title | Clinical outcomes of adjusted-dose versus standard-dose prasugrel in East Asian patients with acute myocardial infarction | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijcard.2024.132197 | - |
dc.identifier.bibliographicCitation | International journal of cardiology, v.410 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85195835576 | - |
dc.citation.title | International journal of cardiology | - |
dc.citation.volume | 410 | - |
dc.type.docType | Journal Article | - |
dc.publisher.location | 아일랜드 | - |
dc.subject.keywordAuthor | Acute myocardial infarction | - |
dc.subject.keywordAuthor | Antiplatelet therapy | - |
dc.subject.keywordAuthor | Bleeding event | - |
dc.subject.keywordAuthor | East Asians | - |
dc.subject.keywordAuthor | Prasugrel | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.