A Randomized Controlled Trial of Thermo-Sensitive Sol-Gel Anti-Adhesion Agent after Gynecologic Surgery
DC Field | Value | Language |
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dc.contributor.author | Kim, Young Im | - |
dc.contributor.author | Lee, Maria | - |
dc.contributor.author | Kim, Se Ik | - |
dc.contributor.author | Seol, Aeran | - |
dc.contributor.author | Lee, Eun Ji | - |
dc.contributor.author | Kim, Hee Seung | - |
dc.contributor.author | Song, Yong Sang | - |
dc.date.accessioned | 2024-06-13T06:30:28Z | - |
dc.date.available | 2024-06-13T06:30:28Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74160 | - |
dc.description.abstract | Postoperative abdominal adhesions can lead to several adverse consequences such as pelvic pain, bowel obstruction, and infertility. We aimed to explore the anti-adhesion efficacy and safety of a thermo-sensitive sol-gel agent in patients who receive abdominopelvic surgery for benign gynecologic disease. This study was a randomized, controlled, single-blind clinical trial of women undergoing benign gynecologic surgery between January 2017 and December 2017. The patients were randomly assigned to three groups with a 1:1:1 ratio: experimental group (received the thermo-sensitive sol-gel agent), control group (untreated), and comparator group (received 4% icodextrin). Patients were followed for 4 weeks postoperatively, and efficacy was evaluated by performing the visceral slide test to identify adhesion formation. In total, 183 patients were enrolled in the study, and 178 (97.3%) completed the trial. The incidence rate of abdominal adhesion formation was significantly lower in the experimental group than in the control group (7.9% vs. 21.1%,p= 0.040); however, it was similar between the experimental and comparator groups (7.9% vs. 13.8%.p= 0.299). At 4 weeks, no differences in adhesion-related symptoms were observed between the experimental and control groups. Adverse events were mostly mild and did not differ significantly among the three groups (p= 0.375). In conclusion, use of a thermo-sensitive sol-gel agent was safe and effective to prevent abdominal adhesions after benign gynecologic surgeries. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | A Randomized Controlled Trial of Thermo-Sensitive Sol-Gel Anti-Adhesion Agent after Gynecologic Surgery | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/jcm9072261 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.9, no.7 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000557676500001 | - |
dc.identifier.scopusid | 2-s2.0-85114272697 | - |
dc.citation.number | 7 | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | abdominal adhesion | - |
dc.subject.keywordAuthor | gynecologic surgery | - |
dc.subject.keywordAuthor | anti-adhesion agent | - |
dc.subject.keywordAuthor | thermo-sensitive agent | - |
dc.subject.keywordAuthor | sol-gel process | - |
dc.subject.keywordPlus | POSTOPERATIVE ADHESIONS | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | LAPAROSCOPIC SURGERY | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | ENDOMETRIOSIS | - |
dc.subject.keywordPlus | ETIOLOGY | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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