Device Closure or Antithrombotic Therapy After Cryptogenic Stroke in Elderly Patients With a High-Risk Patent Foramen Ovale
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Pil Hyung | - |
dc.contributor.author | Kim, Jung-Sun | - |
dc.contributor.author | Song, Jae-Kwan | - |
dc.contributor.author | Kwon, Sun U | - |
dc.contributor.author | Kim, Bum Joon | - |
dc.contributor.author | Lee, Ji Sung | - |
dc.contributor.author | Sun, Byung Joo | - |
dc.contributor.author | Woo, Jong Shin | - |
dc.contributor.author | Ann, Soe Hee | - |
dc.contributor.author | Suh, Jung-Won | - |
dc.contributor.author | Kim, Jun Yup | - |
dc.contributor.author | Lee, Kyusup | - |
dc.contributor.author | Lee, Sang Yeub | - |
dc.contributor.author | Heo, Ran | - |
dc.contributor.author | Jeong, Soo | - |
dc.contributor.author | Jang, Jeong Yoon | - |
dc.contributor.author | Bae, Jang-Whan | - |
dc.contributor.author | Kim, Young Dae | - |
dc.contributor.author | Heo, Sung Hyuk | - |
dc.contributor.author | Kim, Jong S | - |
dc.date.accessioned | 2024-06-17T06:31:11Z | - |
dc.date.available | 2024-06-17T06:31:11Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 2287-6391 | - |
dc.identifier.issn | 2287-6405 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74282 | - |
dc.description.abstract | OBJECTIVE: In young patients (aged 18-60 years) with patent foramen ovale (PFO)-associated stroke, percutaneous closure has been found to be useful for preventing recurrent ischemic stroke or transient ischemic attack (TIA). However, it remains unknown whether PFO closure is also beneficial in older patients. METHODS: Patients aged ≥60 years who had a cryptogenic stroke and PFO from ten hospitals in South Korea were included. The effect of PFO closure plus medical therapy over medical therapy alone was assessed by a propensity-score matching method in the overall cohort and in those with a high-risk PFO, characterized by the presence of an atrial septal aneurysm or a large shunt. RESULTS: Out of the 437 patients (mean age, 68.1), 303 (69%) had a high-risk PFO and 161 (37%) patients underwent PFO closure. Over a median follow-up of 3.9 years, recurrent ischemic stroke or TIA developed in 64 (14.6%) patients. In the propensity score-matched cohort of the overall patients (130 pairs), PFO closure was associated with a significantly lower risk of a composite of ischemic stroke or TIA (hazard ratio [HR]: 0.45; 95% confidence interval [CI]: 0.24-0.84; P=0.012), but not for ischemic stroke. In a subgroup analysis of confined to the high-risk PFO patients (116 pairs), PFO closure was associated with significantly lower risks of both the composite of ischemic stroke or TIA (HR: 0.40; 95% CI: 0.21-0.77; P=0.006) and ischemic stroke (HR: 0.47; 95% CI: 0.23-0.95; P=0.035). CONCLUSIONS: Elderly patients with cryptogenic stroke and PFO have a high recurrence rate of ischemic stroke or TIA, which may be significantly reduced by device closure. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Stroke Society | - |
dc.title | Device Closure or Antithrombotic Therapy After Cryptogenic Stroke in Elderly Patients With a High-Risk Patent Foramen Ovale | - |
dc.type | Article | - |
dc.identifier.doi | 10.5853/jos.2023.03265 | - |
dc.identifier.bibliographicCitation | Journal of stroke, v.26, no.2, pp 242 - 251 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85196555082 | - |
dc.citation.endPage | 251 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 242 | - |
dc.citation.title | Journal of stroke | - |
dc.citation.volume | 26 | - |
dc.type.docType | Journal Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Cryptogenic stroke | - |
dc.subject.keywordAuthor | Device closure | - |
dc.subject.keywordAuthor | Elderly patients | - |
dc.subject.keywordAuthor | Patent foramen ovale | - |
dc.subject.keywordAuthor | Stroke prevention | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.