Prognostic Implication of Platelet Reactivity According to Procedural Complexity After PCI: Subanalysis of PTRG-DES Consortium
DC Field | Value | Language |
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dc.contributor.author | Jin, Xuan | - |
dc.contributor.author | Jeong, Young-Hoon | - |
dc.contributor.author | Lee, Kwang Min | - |
dc.contributor.author | Yun, Sung Cheol | - |
dc.contributor.author | Kim, Byeong-Keuk | - |
dc.contributor.author | Joo, Hyung Joon | - |
dc.contributor.author | Chang, Kiyuk | - |
dc.contributor.author | Park, Yong Whi | - |
dc.contributor.author | Song, Young Bin | - |
dc.contributor.author | Ahn, Sung Gyun | - |
dc.contributor.author | Suh, Jung-Won | - |
dc.contributor.author | Lee, Sang Yeub | - |
dc.contributor.author | Cho, Jung Rae | - |
dc.contributor.author | Her, Ae-Young | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.contributor.author | Lim, Do-Sun | - |
dc.contributor.author | Shin, Eun-Seok | - |
dc.contributor.author | Kim, Moo Hyun | - |
dc.date.accessioned | 2024-06-17T07:01:24Z | - |
dc.date.available | 2024-06-17T07:01:24Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 2772-3747 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74287 | - |
dc.description.abstract | Background: Complex percutaneous coronary intervention (C-PCI) and high platelet reactivity (HPR) have been proposed as representative risk factors for the high ischemic phenotype. Uncertainty remains regarding the relative prognostic importance of these factors. Objectives: This study aimed to investigate the prognostic implication of HPR according to procedural complexity. Methods: Patients treated with drug-eluting stent implantation (PTRG-PFT cohort; N = 11,714) were classified according to procedural complexity. HPR criteria were determined using VerifyNow (≥252 P2Y12 reaction units). The major adverse cardiac and cerebrovascular events (MACCE) (the composite of all-cause death, myocardial infarction, definite stent thrombosis, or stroke) and major bleeding were assessed for up to 3 years. Results: C-PCI was performed in 3,152 patients (26.9%). C-PCI significantly increased the risk of MACCE (HRadjusted: 1.21; 95% CI: 1.01-1.44; P = 0.035), driven by a higher rate of all-cause death (HRadjusted: 1.45; 95% CI: 1.15-1.83; P = 0.002), although it did not increase the risk of major bleeding. Irrespective of procedural complexity, the HPR phenotype was significantly associated with MACCE (Pinteraction = 0.731) and all-cause mortality (Pinteraction = 0.978), in which the prognostic implication appeared prominent within 1 year. The HPR phenotype did not show a significant interaction with any type of C-PCI. In addition, the number of complexity features per procedure did not proportionally increase the risk of MACCE. Conclusions: C-PCI was significantly associated with 3-year risk of MACCE and all-cause death. The HPR phenotype appears to have a similar prognostic implication irrespective of the type and extent of procedural complexity. (Platelet Function and Genotype-Related Long-Term Prognosis in DES-Treated Patients [PTRG-DES]; NCT04734028) © 2023 The Authors | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Prognostic Implication of Platelet Reactivity According to Procedural Complexity After PCI: Subanalysis of PTRG-DES Consortium | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jacasi.2023.10.011 | - |
dc.identifier.bibliographicCitation | JACC: Asia, v.4, no.3, pp 185 - 198 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85182704761 | - |
dc.citation.endPage | 198 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 185 | - |
dc.citation.title | JACC: Asia | - |
dc.citation.volume | 4 | - |
dc.type.docType | Article in press | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | clinical outcomes | - |
dc.subject.keywordAuthor | complex PCI | - |
dc.subject.keywordAuthor | platelet reactivity | - |
dc.description.journalRegisteredClass | scopus | - |
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