Salvia miltiorrhiza bunge extracts: a promising source for anti-atopic dermatitis activity
DC Field | Value | Language |
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dc.contributor.author | Ryu, Da Hye | - |
dc.contributor.author | Cho, Jwa Yeong | - |
dc.contributor.author | Yu, Hyung-Seok | - |
dc.contributor.author | Kim, Jin-Woo | - |
dc.contributor.author | Kim, Jin-Chul | - |
dc.contributor.author | Son, Yang-Ju | - |
dc.contributor.author | Nho, Chu Won | - |
dc.contributor.author | Hamayun, Muhammad | - |
dc.contributor.author | Kim, Ho-Youn | - |
dc.date.accessioned | 2024-06-25T05:00:25Z | - |
dc.date.available | 2024-06-25T05:00:25Z | - |
dc.date.issued | 2024-06 | - |
dc.identifier.issn | 2662-7671 | - |
dc.identifier.issn | 2662-7671 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74371 | - |
dc.description.abstract | BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory condition characterized by the accumulation of reactive oxygen species and the expression of inflammatory factors. Regarding its anti-atopic activity, numerous traditional medicinal materials and secondary metabolic products play pivotal roles in modulating the associated mechanisms. METHODS: This study aimed to utilize Salvia miltiorrhiza Bunge (SMB) as an anti-AD source. In-vitro activity assessments and qualitative and quantitative analyses using UPLC-TQ-MS/MS and HPLC-DAD were conducted in two cultivars ('Dasan' and 'Kosan'). Statistical analysis indicated that the profiles of their secondary metabolites contribute significantly to their pharmacological properties. Consequently, bio-guided fractionation was undertaken to figure out the distinct roles of the secondary metabolites present in SMB. RESULTS: Comparative study of two cultivars indicated that 'Dasan', having higher salvianolic acid A and B, exhibited stronger antioxidant and anti-inflammatory activities. Meanwhile, 'Kosan', containing higher tanshinones, showed higher alleviating activities on anti-AD related genes in mRNA levels. Additionally, performed bio-guided fractionation re-confirmed that the hydrophilic compounds of SMB can prevent AD by inhibiting accumulation of ROS and suppressing inflammatory factors and the lipophilic components can directly inhibit AD. CONCLUSIONS: SMB was revealed as a good source for anti-AD activity. Several bioactive compounds were identified from the UPLC-TQ-MS/MS and different compounds content was linked to biological activities. Characterization of these compounds may be helpful to understand differential role of secondary metabolites from SMB on alleviation of AD. © 2024. The Author(s). | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMC | - |
dc.title | Salvia miltiorrhiza bunge extracts: a promising source for anti-atopic dermatitis activity | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12906-024-04524-z | - |
dc.identifier.bibliographicCitation | BMC complementary medicine and therapies, v.24, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001240748700001 | - |
dc.identifier.scopusid | 2-s2.0-85195438587 | - |
dc.citation.number | 1 | - |
dc.citation.title | BMC complementary medicine and therapies | - |
dc.citation.volume | 24 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Salvia miltiorrhiza Bunge | - |
dc.subject.keywordAuthor | Anti-atopic dermatitis | - |
dc.subject.keywordAuthor | Anti-inflammatory | - |
dc.subject.keywordAuthor | Antioxidant | - |
dc.subject.keywordAuthor | Bio-guided fractionation | - |
dc.subject.keywordAuthor | HPLC-DAD | - |
dc.subject.keywordAuthor | Phenolics | - |
dc.subject.keywordAuthor | Tanshinones | - |
dc.subject.keywordAuthor | UPLC-TQ-MS/MS | - |
dc.subject.keywordPlus | ACID B PROTECTS | - |
dc.subject.keywordPlus | ANTIOXIDANT PROPERTIES | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | CHEMOKINES | - |
dc.subject.keywordPlus | INTERPLAY | - |
dc.subject.keywordPlus | ISCHEMIA | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | BARRIER | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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