Cellular and viral determinants of retroviral nuclear entry
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bin Hamid, Faysal | - |
dc.contributor.author | Kim, Jinsun | - |
dc.contributor.author | Shin, Cha-Gyun | - |
dc.date.available | 2019-03-08T13:56:57Z | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 0008-4166 | - |
dc.identifier.issn | 1480-3275 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7443 | - |
dc.description.abstract | Retroviruses must integrate their cDNA into the host genome to generate proviruses. Viral DNA-protein complexes interact with cellular proteins and produce pre-integration complexes, which carry the viral genome and cross the nuclear pore channel to enter the nucleus and integrate viral DNA into host chromosomal DNA. If the reverse transcripts fail to integrate, linear or circular DNA species such as 1- and 2-long terminal repeats are generated. Such complexes encounter numerous cellular proteins in the cytoplasm, which restrict viral infection and protect the nucleus. To overcome host cell defenses, the pathogens have evolved several evasion strategies. Viral proteins often contain nuclear localization signals, allowing entry into the nucleus. Among more than 1000 proteins identified as required for HIV infection by RNA interference screening, karyopherins, cleavage and polyadenylation specific factor 6, and nucleoporins have been predominantly studied. This review discusses current opinions about the synergistic relationship between the viral and cellular factors involved in nuclear import, with focus on the unveiled mysteries of the host-pathogen interaction, and highlights novel approaches to pinpoint therapeutic targets. | - |
dc.format.extent | 15 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS | - |
dc.title | Cellular and viral determinants of retroviral nuclear entry | - |
dc.type | Article | - |
dc.identifier.doi | 10.1139/cjm-2015-0350 | - |
dc.identifier.bibliographicCitation | CANADIAN JOURNAL OF MICROBIOLOGY, v.62, no.1, pp 1 - 15 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000370050100001 | - |
dc.identifier.scopusid | 2-s2.0-84951293118 | - |
dc.citation.endPage | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | CANADIAN JOURNAL OF MICROBIOLOGY | - |
dc.citation.volume | 62 | - |
dc.type.docType | Review | - |
dc.publisher.location | 캐나다 | - |
dc.subject.keywordAuthor | HIV-1 | - |
dc.subject.keywordAuthor | PIC | - |
dc.subject.keywordAuthor | nuclear import | - |
dc.subject.keywordAuthor | TNPO3 | - |
dc.subject.keywordAuthor | 2-LTR | - |
dc.subject.keywordPlus | IMMUNODEFICIENCY-VIRUS TYPE-1 | - |
dc.subject.keywordPlus | CENTRAL DNA FLAP | - |
dc.subject.keywordPlus | FACTOR I-M | - |
dc.subject.keywordPlus | HIV-1 INTEGRASE | - |
dc.subject.keywordPlus | PORE COMPLEX | - |
dc.subject.keywordPlus | NONDIVIDING CELLS | - |
dc.subject.keywordPlus | LOCALIZATION SIGNAL | - |
dc.subject.keywordPlus | IMPORTIN-BETA | - |
dc.subject.keywordPlus | NUCLEOPORIN NUP153 | - |
dc.subject.keywordPlus | PROTEIN IMPORT | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.