Thyroglobulin in Washout Fluid From Lymph Node Fine-needle Aspiration Biopsy in Papillary Thyroid Cancer: Large-scale Validation of the Cutoff Value to Determine Malignancy and Evaluation of Discrepant Results
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dc.contributor.author | Moon, Jae Hoon | - |
dc.contributor.author | Kim, Yong Il | - |
dc.contributor.author | Lim, Jung Ah | - |
dc.contributor.author | Choi, Hoon Sung | - |
dc.contributor.author | Cho, Sun Wook | - |
dc.contributor.author | Kim, Kyung Won | - |
dc.contributor.author | Park, Hyo Jin | - |
dc.contributor.author | Paeng, Jin Chul | - |
dc.contributor.author | Park, Young Joo | - |
dc.contributor.author | Yi, Ka Hee | - |
dc.contributor.author | Park, Do Joon | - |
dc.contributor.author | Kim, Sang Eun | - |
dc.contributor.author | Chung, June-Key | - |
dc.date.accessioned | 2024-07-02T01:01:19Z | - |
dc.date.available | 2024-07-02T01:01:19Z | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.issn | 1945-7197 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74480 | - |
dc.description.abstract | Context: There are still some controversies regarding the cutoff value and the influential factors of thyroglobulin (Tg) concentration in washout fluid from fine-needle aspiration (FNA) biopsy (FNA-Tg) on cervical lymph nodes (LNs) in patients with papillary thyroid cancer (PTC). Objective: Our aims were to validate the cutoff value of FNA-Tg in diagnosing malignant LNs on a large scale and to investigate the influential factors that could result in the discrepancy between the final diagnosis and FNA-Tg. Design, Setting, and Participants: We conducted a retrospective cohort study based on hospital records with 528 cases of FNA-Tg measurement from 419 PTC patients. Main Outcome Measure: The cutoff value of FNA-Tg was obtained from receiver operating characteristic analysis with final diagnosis. Binary logistic regression analysis was performed to investigate the influential factors. Results: In the final diagnosis, 190 LNs were malignant, and 338 LNs were benign. The median FNA-Tg was 521.2 (3676.8) ng/mL in malignant LNs, and 0.1 (0.2) ng/mL in benign LNs. The optimal cutoff value of FNA-Tg in distinguishing malignant LNs from benign LNs was 1.0 ng/mL (sensitivity, 93.2%; specificity, 95.9%) in all cases. Combining FNA-Tg and FNA cytology showed superior diagnostic power (sensitivity, 98.4%; specificity, 94.4%) when compared with diagnostic strategy using either FNA cytology or FNA-Tg alone. FNA-Tg, serum TSH, and serum Tg were higher in nonthyroidectomized patients than in thyroidectomized patients (P <.001, respectively). FNA-Tg was correlated with serum TSH and Tg levels (P <.001, respectively), and binary logistic regression analysis showed that serum TSH suppression and serum Tg presence independently affected the diagnosis made by FNA-Tg. Conclusions: Our results validated 1.0 ng/mL of FNA-Tg as a cutoff value for diagnosing LN metastasis of PTC and suggested that serum TSH suppression and serum Tg presence should be considered in diagnosing LN malignancy with FNA-Tg in PTC patients. (J Clin Endocrinol Metab 98: 1061-1068, 2013) | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ENDOCRINE SOC | - |
dc.title | Thyroglobulin in Washout Fluid From Lymph Node Fine-needle Aspiration Biopsy in Papillary Thyroid Cancer: Large-scale Validation of the Cutoff Value to Determine Malignancy and Evaluation of Discrepant Results | - |
dc.type | Article | - |
dc.identifier.doi | 10.1210/jc.2012-3291 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.98, no.3, pp 1061 - 1068 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000316417200054 | - |
dc.identifier.scopusid | 2-s2.0-84874893111 | - |
dc.citation.endPage | 1068 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1061 | - |
dc.citation.title | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.citation.volume | 98 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | NECK ULTRASONOGRAPHY | - |
dc.subject.keywordPlus | SERUM THYROGLOBULIN | - |
dc.subject.keywordPlus | DIAGNOSTIC-VALUE | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | METASTASES | - |
dc.subject.keywordPlus | INCLUSIONS | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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