Serum Preadipocyte Factor 1 Levels Are Not Associated with Bone Mineral Density among Healthy Postmenopausal Korean Women
DC Field | Value | Language |
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dc.contributor.author | Choi, Hoon Sung | - |
dc.contributor.author | Kim, Sang-Wook | - |
dc.contributor.author | Cho, Eun-Hee | - |
dc.date.accessioned | 2024-07-02T01:01:44Z | - |
dc.date.available | 2024-07-02T01:01:44Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.issn | 2093-5978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74487 | - |
dc.description.abstract | Background: Multipotent mesenchymal stem cells can differentiate into adipocytes or osteoblasts through closely regulated lineagecontrol processes. However, adipocyte precursor cells release preadipocyte factor 1 (Pref-1), which inhibits the differentiation of mesenchymal stem cells into mature adipocytes and osteoblasts. Previous studies have also reported an inverse association between Pref-1 levels and bone mineral density (BMD) among patients with anorexia nervosa. Methods: In this retrospective study, we examined the correlations between Pref-1 levels and BMD among 124 healthy postmenopausal women (>50 years old). The patients had provided information regarding their clinical characteristics, and underwent blood testing and serum Pref-1 testing. Results: The subjects' mean age was 59.9 +/- 7.1 years and the median time since menopause onset was 9.1 years. A history of osteoporotic fracture was identified in 23 subjects (19%). Serum Pref-1 levels were not significantly correlated with BMD values at the lumbar spine (R-2=0.038, P=0.109), femur neck (R-2=0.017, P=0.869), and total hip (R-2=0.041, P=0.09), and multivariate analyses with adjustment for age and body mass index also did not detect any significant correlations. Subgroup analyses according to a history of fracture also did not detect significant associations between Pref-1 levels and BMD values. Conclusion: In our study population, it does not appear that serum Pref-1 levels are significantly associated with BMD values and osteoporosis. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ENDOCRINE SOC | - |
dc.title | Serum Preadipocyte Factor 1 Levels Are Not Associated with Bone Mineral Density among Healthy Postmenopausal Korean Women | - |
dc.type | Article | - |
dc.identifier.doi | 10.3803/EnM.2017.32.1.124 | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY AND METABOLISM, v.32, no.1, pp 124 - 128 | - |
dc.identifier.kciid | ART002207653 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000407810100019 | - |
dc.identifier.scopusid | 2-s2.0-85015946224 | - |
dc.citation.endPage | 128 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 124 | - |
dc.citation.title | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.volume | 32 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Preadipocyte factor 1 | - |
dc.subject.keywordAuthor | Postmenopausal women | - |
dc.subject.keywordAuthor | Bone density | - |
dc.subject.keywordAuthor | Osteoporosis | - |
dc.subject.keywordPlus | FACTOR-I LEVELS | - |
dc.subject.keywordPlus | ANOREXIA-NERVOSA | - |
dc.subject.keywordPlus | OSTEOPOROSIS | - |
dc.subject.keywordPlus | ADIPOSITY | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | STRENGTH | - |
dc.subject.keywordPlus | ESTROGEN | - |
dc.subject.keywordPlus | PREF-1 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | FAT | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
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