Liver-Wrapping, Nitric Oxide-Releasing Nanofiber Downregulates Cleaved Caspase-3 and Bax Expression on Rat Hepatic Ischemia-Reperfusion Injury
DC Field | Value | Language |
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dc.contributor.author | Ko, H. M. | - |
dc.contributor.author | Joo, S. H. | - |
dc.contributor.author | Jo, J. H. | - |
dc.contributor.author | Park, W. S. | - |
dc.contributor.author | Jung, W. Y. | - |
dc.contributor.author | Shin, J. H. | - |
dc.contributor.author | Ahn, H. J. | - |
dc.date.accessioned | 2024-07-08T06:30:37Z | - |
dc.date.available | 2024-07-08T06:30:37Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.issn | 1873-2623 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74639 | - |
dc.description.abstract | Background. Hepatic ischemia-reperfusion injury (IRI) is an important determinant of the outcome of hepatic surgery, including re-section and transplantation. Previous studies have shown that nitric oxide (NO) has a protective effect against IRI. Therefore, many studies have examined methods for supplying NO. In this study, we investigated the effect of NO-releasing nanofibers on hepatic IRI in a rat model. Methods. Male Sprague-Dawley rats were divided into 4 groups: control, IRI only (n = 3); group 1, hepatic IRI and liver-wrapping with nanofiber lacking NO (n = 4); group 2, hepatic IRI and liver-wrapping with NO rapid-releasing nanofiber (n = 4); and group 3, hepatic IRI and liver-wrapping with NO slow-releasing nanofiber (n = 5). Results. The levels of aspartate aminotransferase and alanine aminotransferase were not significantly different between groups. On the basis of Western blots, Bax/beta-actin levels were significantly lower in group 2 than in group 3 (P < .01). Cleaved Caspase-3/beta-actin levels were significantly lower in group 2 than in the control, group 1, and group 3 (P < .05,.01, and .01, respectively). However, there were no significant differences in Bcl-2/beta-actin between groups. Conclusions. The liver-wrapping NO rapid-releasing nanofiber downregulated cleaved Caspase-3 and Bax expression. It has a protective effect by reducing apoptosis in hepatic IRI in rats. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Liver-Wrapping, Nitric Oxide-Releasing Nanofiber Downregulates Cleaved Caspase-3 and Bax Expression on Rat Hepatic Ischemia-Reperfusion Injury | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.transproceed.2017.03.054 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION PROCEEDINGS, v.49, no.5, pp 1170 - 1174 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000403382400053 | - |
dc.identifier.scopusid | 2-s2.0-85020130616 | - |
dc.citation.endPage | 1174 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1170 | - |
dc.citation.title | TRANSPLANTATION PROCEEDINGS | - |
dc.citation.volume | 49 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | RENAL ISCHEMIA | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | KIDNEY | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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