A comparison among infusion of lidocaine and dexmedetomidine alone and in combination in subjects undergoing coronary artery bypass graft: A randomized trial
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyo-Jin | - |
dc.contributor.author | Kim, Won Ho | - |
dc.contributor.author | Kim, Gahyun | - |
dc.contributor.author | Kim, Eunhee | - |
dc.contributor.author | Park, Mi-Hye | - |
dc.contributor.author | Shin, Byung Seop | - |
dc.contributor.author | Sim, Woo Seog | - |
dc.contributor.author | Kim, Chung Su | - |
dc.contributor.author | Lee, Young Tak | - |
dc.contributor.author | Cho, Hyun Sung | - |
dc.date.accessioned | 2024-07-10T02:30:26Z | - |
dc.date.available | 2024-07-10T02:30:26Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 1551-7144 | - |
dc.identifier.issn | 1559-2030 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/74662 | - |
dc.description.abstract | Background: Previous studies have reported the cardioprotective effect of dexmedetomidine and lidocaine. We compared the effect of lidocaine and dexmedetomidine infusion during off-pump coronary artery bypass graft (OPCAB). Methods: 153 patients undergoing OPCAB were enrolled. The lidocaine group (n = 36, Group LIDO) received an infusion of lidocaine 2 mg/kg/h after bolus 1.5 mg/kg; the dexmedetomidine group (n = 40, Group DEX) received dexmedetomidine 03-0.7 mu g/kg/h; the combined group (n = 39, Group Combined) received infusion of both drugs; and the control group (n = 38) received nothing. We measured serum creatinine kinase-myocardial band (CK-MB) and cardiac troponin I (cTnI) concentration before and immediately after the surgery, postoperative day (POD)#1 and #2. The complication rate and clinical outcomes were compared. Results: The concentration of cTnI was significantly lower in the Group LIDO and Group Combined than the control group on POD#2. The concentration of CK-MB was significantly lower in the Group LIDO and Group Combined compared to the control group on POD#1 and #2 [CK-MB on POD#1: 7.67 (5.78-11.92) vs. 7.18 (5.01-11.72) vs. 13.19 (6.85-23.87) in the Group LIDO, combined and control, respectively, Group LIDO vs. control: p = 0.003, Group Combined vs. control: p = 0.015]. The AUC of CK-MB was significantly lower in the Group LIDO and Group Combined than the control group. However, clinical variables including complication rate, ICU stay and one-year mortality were not different. Conclusions: Lidocaine infused at 2 mg/kg/h, but not dexmedetomidine infused at 03-0.7 mu g/kg/h reduced postoperative myocardial injury marker levels compared with the control group. However, no other clinical benefits were observed. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | A comparison among infusion of lidocaine and dexmedetomidine alone and in combination in subjects undergoing coronary artery bypass graft: A randomized trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cct.2014.10.005 | - |
dc.identifier.bibliographicCitation | CONTEMPORARY CLINICAL TRIALS, v.39, no.2, pp 303 - 309 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000346542400014 | - |
dc.identifier.scopusid | 2-s2.0-84908300287 | - |
dc.citation.endPage | 309 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 303 | - |
dc.citation.title | CONTEMPORARY CLINICAL TRIALS | - |
dc.citation.volume | 39 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Lidocaine | - |
dc.subject.keywordAuthor | Dexmedetomidine | - |
dc.subject.keywordAuthor | Anesthesia | - |
dc.subject.keywordAuthor | Coronary artery bypass graft | - |
dc.subject.keywordAuthor | Myocardial injury | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | VENTRICULAR-FIBRILLATION | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | ANESTHESIA | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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