Inhibitory Effect of Standardized Curcuma xanthorrhiza Supercritical Extract on LPS-Induced Periodontitis in Rats
DC Field | Value | Language |
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dc.contributor.author | Kook, Kyo Eun | - |
dc.contributor.author | Kim, Changhee | - |
dc.contributor.author | Kang, Wonku | - |
dc.contributor.author | Hwang, Jae-Kwan | - |
dc.date.available | 2019-01-22T12:37:49Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.issn | 1738-8872 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/747 | - |
dc.description.abstract | Periodontitis, which is a severe inflammatory disease caused by endotoxins secreted from oral pathogens, destructs gingival tissue and alveolar bone. Curcuma xanthorrhiza, commonly called Java turmeric, has been shown to possess anti-bacterial and anti-inflammatory activities. The present study evaluated the inhibitory effect of C. xanthorrhiza supercritical extract (CXS) standardized with xanthorrhizol on lipopolysaccharide (LPS)-induced periodontitis in an animal model. LPS was topically injected into the periodontium of Sprague-Dawley rats to induce periodontitis and CXS (30 and 100 mg.kg(-1).day(-1)) was orally administered after day 12. Histologically, CXS inhibited the collapse of gingival tissue by preventing cell infiltration. CXS significantly downregulated the expression of matrix metalloproteases (MMPs) and inflammation-related biomarkers, such as nuclear factor-kappa B (NF-kappa B) and interleukin-1 beta (IL-1 beta) in gingival tissue. CXS also improved bone remodeling by downregulating osteoclastic transcription factors, such as nuclear factor of activated T-cells c1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K. In addition, CXS upregulated osteoblast differentiation-related markers, alkaline phosphate (ALP) and collagen type I alpha (COLA1). Thus, CXS can ameliorate periodontitis by inhibiting inflammation and improving bone remodeling. | - |
dc.format.extent | 12 | - |
dc.publisher | KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.title | Inhibitory Effect of Standardized Curcuma xanthorrhiza Supercritical Extract on LPS-Induced Periodontitis in Rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.4014/jmb.1808.08052 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.28, no.10, pp 1614 - 1625 | - |
dc.identifier.kciid | ART002397940 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000448398800004 | - |
dc.identifier.scopusid | 2-s2.0-85065180574 | - |
dc.citation.endPage | 1625 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1614 | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Curcuma xanthorrhiza | - |
dc.subject.keywordAuthor | osteoblastogenesis | - |
dc.subject.keywordAuthor | osteoclastogenesis | - |
dc.subject.keywordAuthor | periodontitis | - |
dc.subject.keywordAuthor | periodontal inflammation | - |
dc.subject.keywordPlus | HUMAN GINGIVAL FIBROBLASTS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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