Prediabetes is not a risk factor for subclinical coronary atherosclerosis

Abstract

Background: There are limited data regarding the influence of glycemic status on the risk of subclinical coronary atherosclerosis on coronary computed tomographic angiography (CCTA) in asymptomatic individuals. Methods: We analyzed 6434 asymptomatic individuals who underwent CCTA. The degree and extent of subclinical coronary atherosclerosis were assessed by CCTA, and >= 50% diameter stenosis was defined as significant. Of study participants, 2197 (34.1%), 3122 (48.5%), and 1115 (17.3%) were categorized as normal, prediabetic and diabetic individuals, respectively. Results: Compared with normal individuals, there were no statistically differences in the adjusted odds ratios of prediabetic individuals for significant coronary artery stenosis (0.98, 95% confidence interval [CI] 0.80-1.22, p = 0.888), any plaque (0.96, 95% CI 0.86-1.07, p = 0.483), calcified plaque (0.90, 95% CI 0.79-1.01, p = 0.080), non-calcified plaque (1.02, 95% CI 0.88-1.17, p = 0.803), and mixed plaque (1.00, 95% CI 0.82-1.22, p = 0.983). However, adjusted odds ratios for significant coronary artery stenosis (1.71, 95% CI 1.34-2.19, p < 0.001), any plaque (1.45, 95% CI 1.26-1.68, p < 0.001), calcified plaque (1.35, 95% CI 1.15-1.57, p < 0.001), non-calcified plaque (1.33, 95% CI 1.11-1.59, p = 0.002), and mixed plaque (1.64, 95% CI 1.30-2.07, p < 0.001) of diabetic individuals were significantly higher than those of the normal individuals. Conclusion: In asymptomatic individuals, diabetic individuals had a higher risk for subclinical coronary atherosclerosis, but prediabetic individuals were not associated with an increased risk of subclinical coronary atherosclerosis. (C) 2017 Elsevier B.V. All rights reserved.