Longitudinal quantitative assessment of coronary plaque progression related to body mass index using serial coronary computed tomography angiography
- Authors
- Won, Ki-Bum; Lee, Sang-Eun; Lee, Byoung Kwon; Park, Hyung-Bok; Heo, Ran; Rizvi, Asim; Hadamitzky, Martin; Kim, Yong-Jin; Sung, Ji Min; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J.; Gottlieb, Ilan; Chun, Eun Ju; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; Leipsic, Jonathon A.; Shin, Sanghoon; Choi, Jung Hyun; Virmani, Renu; Samady, Habib; Stone, Peter H.; Berman, Daniel S.; Narula, Jagat; Shaw, Leslee J.; Bax, Jeroen J.; Min, James K.; Chang, Hyuk-Jae
- Issue Date
- May-2019
- Publisher
- OXFORD UNIV PRESS
- Keywords
- atherosclerosis; coronary computed tomography angiography; body mass index; obesity
- Citation
- EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, v.20, no.5, pp 591 - 599
- Pages
- 9
- Journal Title
- EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
- Volume
- 20
- Number
- 5
- Start Page
- 591
- End Page
- 599
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/75144
- DOI
- 10.1093/ehjci/jey192
- ISSN
- 2047-2404
2047-2412
- Abstract
- Aims This study explored the coronary plaque volume change ( PVC) according to the change of percent body mass index (BMI) and categorical BMI group using serial coronary computed tomography angiography (CCTA). Methods and results A total of 1568 subjects who underwent serial CCTA with available BMI at baseline (CCTA1) and follow-up (CCTA2) were included. Median inter-scan period was 3.3 (interquartile range: 2.6-4.6) years. Quantitative assessment of coronary plaque was performed at both scans. All participants were categorized into three BMI (kg/m(2)) groups: normal: <25.0; overweight: 25.0-29.9; and obesity: >= 30.0. During follow-up, there were no significant differences in annualized PVC according to the 5% change of BMI in all BMI groups. Among 1424 (90.8%) subjects in the same BMI group at CCTA1 and CCTA2, a significant difference in annualized (PVC) was observed among the three groups. In 144 (9.2%) subjects with the change in their BMI group at CCTA2 compared their results at CCTA1, annualized PVC was not different compared with subjects in the same BMI group during follow-up. The percent change of BMI was not significantly related to the annualized PVC after adjusting confounding factors. Male gender [odds ratio (OR): 1.38; 95% confidence interval (CI): 1.05-1.81; P=0.022], baseline plaque volume (OR: 1.07; 95% CI: 1.05-1.09; P<0.001), and baseline overweight or obesity (OR: 1.35; 95% CI: 1.04-1.77; P=0.027) were independently associated with coronary plaque progression. Conclusion Over the near term, longitudinal small changes in BMI were not associated with changes in coronary plaque volume although baseline BMI was.
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