High HDL-C levels reduce the risk of obstructive coronary artery disease in asymptomatic diabetics who achieved optimal glycemic control
DC Field | Value | Language |
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dc.contributor.author | Park, Gyung-Min | - |
dc.contributor.author | Lee, Yongjik | - |
dc.contributor.author | Won, Ki-Bum | - |
dc.contributor.author | Yang, Yu Jin | - |
dc.contributor.author | Park, Sangwoo | - |
dc.contributor.author | Ann, Soe Hee | - |
dc.contributor.author | Kim, Yong-Giun | - |
dc.contributor.author | Yang, Dong Hyun | - |
dc.contributor.author | Kang, Joon-Won | - |
dc.contributor.author | Lim, Tae-Hwan | - |
dc.contributor.author | Kim, Hong-Kyu | - |
dc.contributor.author | Choe, Jaewon | - |
dc.contributor.author | Lee, Seung-Whan | - |
dc.contributor.author | Kim, Young-Hak | - |
dc.contributor.author | Kim, Shin-Jae | - |
dc.contributor.author | Lee, Sang-Gon | - |
dc.date.accessioned | 2024-07-25T06:30:34Z | - |
dc.date.available | 2024-07-25T06:30:34Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/75148 | - |
dc.description.abstract | The benefit of a high level of high-density lipoprotein cholesterol (HDL-C) against coronary atherosclerosis risk after achieving optimal glycemic control (OGC) in diabetics remains uncertain. We aimed to evaluate the association between HDL-C and obstructive coronary artery disease (CAD) according to OGC status in diabetics. We analyzed 1,114 asymptomatic diabetics who underwent coronary computed tomographic angiography in a health examination. OGC was defined as hemoglobin A1C <7.0%. Obstructive CAD was defined as the presence of plaques with >= 50% stenosis. Patients with a high HDL-C level (>= 40 mg/dL and >= 50 mg/dL in males and females, respectively) showed a lower prevalence of obstructive CAD than those with a low HDL-C level in the OGC group (8.9% vs. 14.4%; p = 0.046), but not in the non-OGC group (22.3% vs. 23.2%, p = 0.850). Multiple logistic regression models showed that the risk for obstructive CAD was lower in patients with a high HDL-C level than in those with a low HDL-C level in the OGC group (odds ratio: 0.584, 95% confidence interval: 0.343-0.995; p = 0.048), but not in the non-OGC group. In conclusion, it may be necessary to maintain a high HDL-C level to reduce the risk of obstructive CAD in asymptomatic diabetics after OGC is achieved. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | High HDL-C levels reduce the risk of obstructive coronary artery disease in asymptomatic diabetics who achieved optimal glycemic control | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-019-51732-6 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.9 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000492825800016 | - |
dc.identifier.scopusid | 2-s2.0-85074168942 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY ANGIOGRAPHY | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | CALCIFICATION | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | ISCHEMIA | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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