Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography Registry
DC Field | Value | Language |
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dc.contributor.author | Park, Gyung-Min | - |
dc.contributor.author | Lee, Chang Hoon | - |
dc.contributor.author | Lee, Seung-Whan | - |
dc.contributor.author | Yun, Sung-Cheol | - |
dc.contributor.author | Kim, Young-Hak | - |
dc.contributor.author | Kim, Yong-Giun | - |
dc.contributor.author | Won, Ki-Bum | - |
dc.contributor.author | Ann, Soe Hee | - |
dc.contributor.author | Kim, Shin-Jae | - |
dc.contributor.author | Yang, Dong Hyun | - |
dc.contributor.author | Kang, Joon-Won | - |
dc.contributor.author | Lim, Tae-Hwan | - |
dc.contributor.author | Koh, Eun Hee | - |
dc.contributor.author | Lee, Woo Je | - |
dc.contributor.author | Kim, Min-Seon | - |
dc.contributor.author | Park, Joong-Yeol | - |
dc.contributor.author | Kim, Hong-Kyu | - |
dc.contributor.author | Choe, Jaewon | - |
dc.contributor.author | Lee, Sang-Gon | - |
dc.date.accessioned | 2024-07-25T07:02:12Z | - |
dc.date.available | 2024-07-25T07:02:12Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.issn | 2233-6087 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/75154 | - |
dc.description.abstract | Background: There are limited data on the impact of diabetes control on the risk of subclinical coronary atherosclerosis. Methods: We analyzed 6,434 consecutive asymptomatic individuals without previous history of coronary artery disease who underwent coronary computed tomographic angiography (CCTA) (mean age, 53.7 +/- 7.6 years and 4,694 men [73.0%]). The degree and extent of subclinical coronary atherosclerosis were assessed by CCTA, and >= 50% diameter stenosis was defined as significant. A cardiac event was defined as a composite of all-cause death, myocardial infarction, unstable angina, or coronary revascularization. Study participants were categorized as normal (n = 5,319), controlled diabetes (glycosylated hemoglobin [HbA1c] < 7%, n = 747), or uncontrolled diabetes (HbA1c = 7%, n=368), respectively. Results: Compared with normal individuals, there were no statistically significant differences in the risk of for any atherosclerotic plaque (odds ratio [OR], 1.16; 95% confidence interval [CI], 0.98 to 1.38; P=0.086) and significant coronary artery stenosis (OR, 1.08; 95% CI, 0.82 to 1.42; P = 0.583) in controlled diabetic individuals. In contrast, uncontrolled diabetic individuals had consistently higher risks of any atherosclerotic plaque (OR, 2.16; 95% CI, 1.70 to 2.75; P<0.001) and significant coronary artery stenosis (OR, 3.34; 95% CI, 2.52 to 4.43; P < 0.001) than normal individuals. During a follow-up of median 5.4 years, there was no significant difference in cardiac events between normal and controlled diabetic individuals (P = 0.365). However, uncontrolled diabetes was associated with an increased risk of cardiac events compared with normal individuals (P<0.001) and controlled diabetic individuals (P=0.023). Conclusion: Asymptomatic uncontrolled diabetes was associated with significant subclinical coronary atherosclerosis with subsequent high risk for cardiac events. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN DIABETES ASSOC | - |
dc.title | Impact of Diabetes Control on Subclinical Atherosclerosis: Analysis from Coronary Computed Tomographic Angiography Registry | - |
dc.type | Article | - |
dc.identifier.doi | 10.4093/dmj.2019.0073 | - |
dc.identifier.bibliographicCitation | DIABETES & METABOLISM JOURNAL, v.44, no.3, pp 470 - 479 | - |
dc.identifier.kciid | ART002596914 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000546443300011 | - |
dc.identifier.scopusid | 2-s2.0-85083400917 | - |
dc.citation.endPage | 479 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 470 | - |
dc.citation.title | DIABETES & METABOLISM JOURNAL | - |
dc.citation.volume | 44 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Coronary artery disease | - |
dc.subject.keywordAuthor | Diabetes complications | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordPlus | INTENSIVE GLUCOSE CONTROL | - |
dc.subject.keywordPlus | ARTERY-DISEASE | - |
dc.subject.keywordPlus | PROGNOSTIC VALUE | - |
dc.subject.keywordPlus | CT ANGIOGRAPHY | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | COMPLICATIONS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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