Body Mass Index and Major Adverse Events During Chronic Antiplatelet Monotherapy After Percutaneous Coronary Intervention With Drug-Eluting Stents-Results From the HOST-EXAM Trial
DC Field | Value | Language |
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dc.contributor.author | Won, Ki-Bum | - |
dc.contributor.author | Shin, Eun-Seok | - |
dc.contributor.author | Kang, Jeehoon | - |
dc.contributor.author | Yang, Han-Mo | - |
dc.contributor.author | Park, Kyung Woo | - |
dc.contributor.author | Han, Kyoo-Rok | - |
dc.contributor.author | Moon, Keon-Woong | - |
dc.contributor.author | Oh, Seok Kyu | - |
dc.contributor.author | Kim, Ung | - |
dc.contributor.author | Rhee, Moo-Yong | - |
dc.contributor.author | Kim, Doo-Il | - |
dc.contributor.author | Kim, Song-Yi | - |
dc.contributor.author | Lee, Sung-Yun | - |
dc.contributor.author | Han, Jung-Kyu | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2024-07-26T05:00:24Z | - |
dc.date.available | 2024-07-26T05:00:24Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.issn | 1347-4820 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/75237 | - |
dc.description.abstract | Background: This study evaluated the association of body mass index (BMI) with adverse clinical outcomes during chronic main-tenance antiplatelet monotherapy after percutaneous coronary intervention (PCI) with drug-eluting stents (DES).Methods and Results: Overall, 5,112 patients were stratified (in kg/m2) into underweight (BMI <= 18.4), normal weight (18.5-22.9), overweight (23.0-24.9), obesity (25.0-29.9) and severe obesity (>= 30.0) categories with randomized antiplatelet monotherapy of aspirin 100 mg or clopidogrel 75 mg once daily for 24 months. The primary endpoint was the composite of all-cause death, non-fatal myocardial infarction, stroke, readmission due to acute coronary syndrome and major bleeding of Bleeding Academic Research Consortium type >= 3. Compared with normal weight, the risk of primary composite outcomes was higher in the underweight (hazard ratio [HR] 2.183 [1.199-3.974]), but lower in the obesity (HR 0.730 [0.558-0.954]) and severe obesity (HR 0.518 [0.278-0.966]) categories, which is partly driven by the difference in all-cause death. The risk of major bleeding was significantly higher in the underweight (HR 4.140 [1.704-10.059]) than in the normal weight category. A decrease in categorical BMI was independently asso-ciated with the increased risk of primary composite outcomes.Conclusions: Lower BMI is associated with a higher risk of primary composite outcomes, which is primarily related to the events of all-cause death or major bleeding during chronic maintenance antiplatelet monotherapy after PCI with DES. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | JAPANESE CIRCULATION SOC | - |
dc.title | Body Mass Index and Major Adverse Events During Chronic Antiplatelet Monotherapy After Percutaneous Coronary Intervention With Drug-Eluting Stents-Results From the HOST-EXAM Trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.1253/circj.CJ-22-0344 | - |
dc.identifier.bibliographicCitation | CIRCULATION JOURNAL, v.87, no.2, pp 268 - 276 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000938761600011 | - |
dc.identifier.scopusid | 2-s2.0-85147047497 | - |
dc.citation.endPage | 276 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 268 | - |
dc.citation.title | CIRCULATION JOURNAL | - |
dc.citation.volume | 87 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | Antiplatelet | - |
dc.subject.keywordAuthor | Body mass index | - |
dc.subject.keywordAuthor | Drug-eluting stents | - |
dc.subject.keywordAuthor | Percutaneous coronary intervention | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordPlus | OBESITY PARADOX | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | CARDIOVASCULAR RISK | - |
dc.subject.keywordPlus | ARTERY-DISEASE | - |
dc.subject.keywordPlus | FOCUSED UPDATE | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CLOPIDOGREL | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | ASPIRIN | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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