Effect of Valeriana fauriei Extract on the Neurodevelopmental Proteins Expression and Behavioral Patterns in Maternal Immune Activation Animal Model
DC Field | Value | Language |
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dc.contributor.author | 원한솔 | - |
dc.contributor.author | 김영옥 | - |
dc.contributor.author | 이화영 | - |
dc.contributor.author | 임지윤 | - |
dc.contributor.author | 이상현 | - |
dc.contributor.author | 조익현 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 박춘근 | - |
dc.contributor.author | 김형기 | - |
dc.contributor.author | 권준택 | - |
dc.contributor.author | 김학재 | - |
dc.date.available | 2019-03-08T14:38:35Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 1225-9306 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7867 | - |
dc.description.abstract | Background: Prenatal exposure to infectious and/or inflammatory insults can increase the risk of developing neuropsychiatric disorder such as bipolar disorder, autism, and schizophrenia later in life. We investigated whether Valeriana fauriei (VF) treatment alleviates prepulse inhibition (PPI) deficits and social interaction impairment induced by maternal immune activation (MIA). Methods and Results: Pregnant mice were exposed to polyriboinosinic-polyribocytidilic acid (5㎎/㎏, viral infection mimic) on gestational day 9. The adolescent offspring received daily oral treatment with VF (100㎎/㎏) and injections of clozapine (5㎎/㎏) for 30 days starting on the postnatal day 35. The effects of VF extract treatment on behavioral activity impairment and protein expression were investigated using the PPI analysis, forced swim test (FST), open field test (OFT), social interaction test (SIT), and immunohistochemistry. The MIA-induced offspring showed deficits in the PPI, FST, OFT, and SIT compared to their non MIAinduced counterparts. Treatment with the VF extract significantly recovered the sensorimotor gating deficits and partially recovered the aggressive behavior observed in the SIT. The VF extract also reversed the downregulation of protein expression induced by MIA in the medial prefrontal cortex. Conclusions: Our results provide initial evidence of the fact that the VF extract could reverse MIA-induced behavioral impairment and prevent neurodevelopmental disorders such as schizophrenia. | - |
dc.format.extent | 10 | - |
dc.publisher | 한국약용작물학회 | - |
dc.title | Effect of Valeriana fauriei Extract on the Neurodevelopmental Proteins Expression and Behavioral Patterns in Maternal Immune Activation Animal Model | - |
dc.title.alternative | 쥐오줌풀 추출물이 MIA동물모델에서의 신경발달 단백질의 발현과 행동증상에 미치는 영향 | - |
dc.type | Article | - |
dc.identifier.doi | 10.7783/KJMCS.2016.24.5.341 | - |
dc.identifier.bibliographicCitation | 한국약용작물학회지, v.24, no.5, pp 341 - 350 | - |
dc.identifier.kciid | ART002158239 | - |
dc.description.isOpenAccess | Y | - |
dc.citation.endPage | 350 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 341 | - |
dc.citation.title | 한국약용작물학회지 | - |
dc.citation.volume | 24 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Valeriana fauriei Briq. | - |
dc.subject.keywordAuthor | Maternal Immune Activation | - |
dc.subject.keywordAuthor | Polyriboinosinic-Polyribocytidilic Acid | - |
dc.subject.keywordAuthor | Schizophrenia | - |
dc.description.journalRegisteredClass | kci | - |
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