Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae-Young | - |
dc.contributor.author | Park, Sunghyun | - |
dc.contributor.author | Kim, Kwang-Soo | - |
dc.contributor.author | Ko, Jeong-Jae | - |
dc.contributor.author | Lee, Soohong | - |
dc.contributor.author | Kim, Keun Pil | - |
dc.contributor.author | Park, Kyung-Soon | - |
dc.date.available | 2019-03-08T14:59:07Z | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 2465-9525 | - |
dc.identifier.issn | 2465-9541 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8192 | - |
dc.description.abstract | Sprouty (Spry) genes encode inhibitors of the receptor tyrosine kinase signaling cascade, which plays important roles in stem cells. However, the role of Spry4 in the stemness of embryonic stem cells has not been fully elucidated. Here, we used mouse embryonic stem cells (mESCs) as a model system to investigate the role of Spry4 in the stem cells. Suppression of Spry4 expression results in the decreases of cell proliferation, EB formation and stemness marker expression, suggesting that Spry4 activity is associated with stemness of mESCs. Teratoma assay showed that the cartilage maturation was facilitated in Spry4 knocked down mESCs. Our results suggest that Spry4 is an important regulator of the stemness and differentiation of mESCs. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국발생생물학회 | - |
dc.title | Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.12717/DR.2016.20.2.171 | - |
dc.identifier.bibliographicCitation | 발생과 생식, v.20, no.2, pp 149 - 155 | - |
dc.identifier.kciid | ART002126599 | - |
dc.description.isOpenAccess | Y | - |
dc.citation.endPage | 155 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 149 | - |
dc.citation.title | 발생과 생식 | - |
dc.citation.volume | 20 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Adenosine | - |
dc.subject.keywordAuthor | De novo synthesis | - |
dc.subject.keywordAuthor | Oocyte | - |
dc.subject.keywordAuthor | Developmental competence | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.