Usefulness of interferon-γ release assay for the diagnosis of latent tuberculosis infection in young children
DC Field | Value | Language |
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dc.contributor.author | Yun, K.W. | - |
dc.contributor.author | Kim, Y.K. | - |
dc.contributor.author | Kim, H.R. | - |
dc.contributor.author | Lee, M.K. | - |
dc.contributor.author | Lim, I.S. | - |
dc.date.available | 2019-03-08T15:56:39Z | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 1738-1061 | - |
dc.identifier.issn | 2092-7258 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8619 | - |
dc.description.abstract | Purpose: Latent tuberculosis infection (LTBI) in young children may progress to severe active tuberculosis (TB) disease and serve as a reservoir for future transmission of TB disease. There are limited data on interferon-γ release assay (IGRA) performance in young children, which our research aims to address by investigating the usefulness of IGRA for the diagnosis of LTBI. Methods: We performed a tuberculin skin test (TST) and IGRA on children who were younger than 18 years and were admitted to Chung-Ang University Hospital during May 2011–June 2015. Blood samples for IGRA were collected, processed, and interpreted according to manufacturer protocol. Results: Among 149 children, 31 (20.8%) and 10 (6.7%) were diagnosed with LTBI and active pulmonary TB, respectively. In subjects lacking contact history with active TB patients, TST and IGRA results were positive in 41.4% (29 of 70) and 12.9% (9 of 70) subjects, respectively. The agreement (kappa) of TST and IGRA was 0.123. The control group, consisting of non-TB-infected subjects, showed no correlation between age and changes in interferon-γ concentration after nil antigen, TB-specific antigen, or mitogen stimulation in IGRAs (P=0.384, P=0.176, and P=0.077, respectively). In serial IGRAs, interferon-γ response to TB antigen increased in IGRA-positive LTBI subjects, but did not change considerably in initially IGRA-negative LTBI or control subjects. Conclusion: The lack of decrease in interferon-γ response in young children indicates that IGRA could be considered for this age group. Serial IGRA tests might accurately diagnose LTBI in children lacking contact history with active TB patients. © 2016 by The Korean Pediatric Society. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Pediatric Society | - |
dc.title | Usefulness of interferon-γ release assay for the diagnosis of latent tuberculosis infection in young children | - |
dc.type | Article | - |
dc.identifier.doi | 10.3345/kjp.2016.59.6.256 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pediatrics, v.59, no.6, pp 256 - 261 | - |
dc.identifier.kciid | ART002114878 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-84976407366 | - |
dc.citation.endPage | 261 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 256 | - |
dc.citation.title | Korean Journal of Pediatrics | - |
dc.citation.volume | 59 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Child | - |
dc.subject.keywordAuthor | Interferon-gamma release assay | - |
dc.subject.keywordAuthor | Latent tuberculosis infection | - |
dc.subject.keywordAuthor | Tuberculin skin test | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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