Development of a robust pH-sensitive polyelectrolyte ionomer complex for anticancer nanocarriers
DC Field | Value | Language |
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dc.contributor.author | Lim, Chaemin | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.contributor.author | Lee, Kyung Soo | - |
dc.contributor.author | Hoang, Ngoc Ha | - |
dc.contributor.author | Sim, Taehoon | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.date.available | 2019-03-08T15:57:17Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8655 | - |
dc.description.abstract | A polyelectrolyte ionomer complex ( PIC) composed of cationic and anionic polymers was developed for nanomedical applications. Here, a poly( ethylene glycol)-poly(lactic acid)poly (ethylene imine) triblock copolymer (PEG-PLA-PEI) and a poly(aspartic acid) (P[Asp]) homopolymer were synthesized. These polyelectrolytes formed stable aggregates through electrostatic interactions between the cationic PEI and the anionic P(Asp) blocks. In particular, the addition of a hydrophobic PLA and a hydrophilic PEG to triblock copolyelectrolytes provided colloidal aggregation stability by forming a tight hydrophobic core and steric hindrance on the surface of PIC, respectively. The PIC showed different particle sizes and zeta potentials depending on the ratio of cationic PEI and anionic P(Asp) blocks (C/A ratio). The doxorubicin (dox)-loaded PIC, prepared with a C/A ratio of 8, demonstrated pH-dependent behavior by the deprotonation/protonation of polyelectrolyte blocks. The drug release and the cytotoxicity of the dox-loaded PIC (C/A ratio: 8) increased under acidic conditions compared with physiological pH, due to the destabilization of the formation of the electrostatic core. In vivo animal imaging revealed that the prepared PIC accumulated at the targeted tumor site for 24 hours. Therefore, the prepared pH-sensitive PIC could have considerable potential as a nanomedicinal platform for anticancer therapy. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.title | Development of a robust pH-sensitive polyelectrolyte ionomer complex for anticancer nanocarriers | - |
dc.type | Article | - |
dc.identifier.doi | 10.2147/IJN.S99271 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.11, pp 703 - 713 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000370498300002 | - |
dc.identifier.scopusid | 2-s2.0-84975755138 | - |
dc.citation.endPage | 713 | - |
dc.citation.startPage | 703 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 뉴질랜드 | - |
dc.subject.keywordAuthor | polyelectrolyte ionomer complex | - |
dc.subject.keywordAuthor | PEG-PLA-PEI | - |
dc.subject.keywordAuthor | nanomedicine | - |
dc.subject.keywordAuthor | pH-sensitive | - |
dc.subject.keywordAuthor | animal imaging | - |
dc.subject.keywordPlus | POLY(ASPARTIC ACID-GRAFT-IMIDAZOLE)-BLOCK-POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | DRUG-DELIVERY SYSTEM | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER | - |
dc.subject.keywordPlus | AQUEOUS-SOLUTIONS | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | WATER | - |
dc.subject.keywordPlus | PEG | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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