Rupture force of cell adhesion ligand tethers modulates biological activities of a cell-laden hydrogel
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, M.K. | - |
dc.contributor.author | Park, J. | - |
dc.contributor.author | Wang, X.F. | - |
dc.contributor.author | Roein-Peikar, M. | - |
dc.contributor.author | Ko, E. | - |
dc.contributor.author | Qin, E. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Ha, T. | - |
dc.contributor.author | Kong, H. | - |
dc.date.available | 2019-03-08T15:57:32Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.issn | 1364-548X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8667 | - |
dc.description.abstract | Recent efforts to design a synthetic extracellularmatrix for cell culture, engineering, and therapies greatly contributed to addressing biological roles of types and spatial organization of cell adhesion ligands. It is often suggested that ligand-matrix bond strength is another path to regulate cell adhesion and activities; however tools are lacking. To this end, this study demonstrates that a hydrogel coupled with integrin-binding deoxyribonucleic acid (DNA) tethers with pre-defined rupture forces can modulate cell adhesion, differentiation, and secretion activities due to the changes in the number and, likely, force of cells adhered to a gel. The rupture force of DNA tethers was tuned by altering the spatial arrangement of matrix-binding biotin groups. The DNA tethers were immobilized on a hydrogel of alginate grafted with biotin using avidin. Mesenchymal stem cells showed enhanced adhesion, neural differentiation, and paracrine secretion when cultured on the gel coupled with DNA tethers with higher rupture forces. Such innovative cell-matrix interface engineering would be broadly useful for a series of materials used for fundamental and applied studies on biological cells. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Rupture force of cell adhesion ligand tethers modulates biological activities of a cell-laden hydrogel | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/c6cc00036c | - |
dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.52, no.26, pp 4757 - 4760 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000372662100004 | - |
dc.identifier.scopusid | 2-s2.0-84962069630 | - |
dc.citation.endPage | 4760 | - |
dc.citation.number | 26 | - |
dc.citation.startPage | 4757 | - |
dc.citation.title | CHEMICAL COMMUNICATIONS | - |
dc.citation.volume | 52 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | FATE | - |
dc.subject.keywordPlus | BIOMATERIALS | - |
dc.subject.keywordPlus | INTERFACE | - |
dc.subject.keywordPlus | INTEGRIN | - |
dc.subject.keywordPlus | DENSITY | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.