The Clinical Stages of Sporadic Creutzfeldt-Jakob Disease with Met/Met Genotype in Korean Patients
DC Field | Value | Language |
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dc.contributor.author | Park, So Young | - |
dc.contributor.author | Wang, Min Jeong | - |
dc.contributor.author | Jang, Jae-Won | - |
dc.contributor.author | Park, Young Ho | - |
dc.contributor.author | Lim, Jae-Sung | - |
dc.contributor.author | Youn, Young Chul | - |
dc.contributor.author | Kim, Jungeun | - |
dc.contributor.author | Kim, SangYun | - |
dc.date.available | 2019-03-08T15:58:04Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0014-3022 | - |
dc.identifier.issn | 1421-9913 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8699 | - |
dc.description.abstract | Background: Clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) is currently based on changes occurring in the late disease stages, which limits early-stage detection. Therefore, we investigated the disease course from the vague symptomatic to the terminal phase. Methods: We retrospectively reviewed 36 sCJD patient records, classifying the disease progression into 4 stages based on clinical manifestations: vague symptomatic, possible CJD, probable CJD and chronic vegetative state. We analyzed findings from diffusion-weighted imaging (DWI), electroencephalography (EEG) and cerebrospinal fluid (CSF) 14-3-3 protein testing performed at each stage. Results: In stage 1, the most distinctive feature was DWI hyperintensities in the neocortex, even with negative CSF 14-3-3 protein and EEG results. In stage 2, DWI hyperintensities in the limbic cortex were more remarkable. CSF 14-3-3 protein testing yielded positive results in >80% of patients; EEG showed sensitivity in <30% of patients. With progression toward stage 3, DWI hyperintensities in the subcortical nucleus increased, with a sustained higher rate of hyperintensities in the limbic and neocortical regions. With gradual progression to stage 4, the sensitivity of CSF 14-3-3 protein testing and EEG decreased and increased, respectively within limited data. Conclusions: Understanding disease stage-dependent differences in clinical symptoms and laboratory test results will facilitate early and accurate diagnosis. (C) 2016 S. Karger AG, Basel | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | The Clinical Stages of Sporadic Creutzfeldt-Jakob Disease with Met/Met Genotype in Korean Patients | - |
dc.type | Article | - |
dc.identifier.doi | 10.1159/000445768 | - |
dc.identifier.bibliographicCitation | EUROPEAN NEUROLOGY, v.75, no.5-6, pp 213 - 222 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000378787600002 | - |
dc.identifier.scopusid | 2-s2.0-84964240149 | - |
dc.citation.endPage | 222 | - |
dc.citation.number | 5-6 | - |
dc.citation.startPage | 213 | - |
dc.citation.title | EUROPEAN NEUROLOGY | - |
dc.citation.volume | 75 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Creutzfeldt-Jakob disease | - |
dc.subject.keywordAuthor | Stages | - |
dc.subject.keywordAuthor | Diffusion-weighted MRI | - |
dc.subject.keywordAuthor | Electroencephalography | - |
dc.subject.keywordAuthor | 14-3-3 protein | - |
dc.subject.keywordPlus | DIFFUSION-WEIGHTED MRI | - |
dc.subject.keywordPlus | RAPIDLY PROGRESSIVE DEMENTIA | - |
dc.subject.keywordPlus | EARLY DIAGNOSTIC MARKER | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | CJD | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | PROFILES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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