Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds
DC Field | Value | Language |
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dc.contributor.author | Yin, Jun | - |
dc.contributor.author | Seo, Chang-Seob | - |
dc.contributor.author | Hwang, In Hyeok | - |
dc.contributor.author | Lee, Min Won | - |
dc.contributor.author | Song, Kwang Hoon | - |
dc.date.available | 2019-01-22T12:58:52Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/887 | - |
dc.description.abstract | Obesity, a condition where excess body fat accumulates to the extent, causes a negative effect on health. Previously, we reported the extract of Dolichos lablab L. (DLL-Ex) inhibited high-fat diet (HFD)-induced increases in body weight and body fat mass and ameliorated increases in body weight. In the present work, we studyed the molecular mechanism for the inhibitory effect of DLL-Ex or Chikusetsusaponin IVa (CS-IVa), as isolated from Dolichos lablab L. (DLL) seeds extract, on adipocyte differentiation. We evaluated the effect of DLL-Ex, an anti-obesity agent, and CS-IVa, an active component of DLL-Ex, on 3T3-L1 cell differentiation via Oil red O assay and Q-PCR, along with their effects on CCAAT element binding protein alpha (C/EBP), peroxisome proliferator-activated receptor gamma (PPAR), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4) mRNA transcriptions. FAS and FABP4 protein expression levels after exposure to CS-IVa were also tested. The results showed that DLL-Ex and CS-IVa have potent inhibitory activity on adipocyte differentiation. Therefore, DLL and CS-IVa may be developed as a functional food material to treat obesity. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/nu10091221 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.10, no.9 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000448659900094 | - |
dc.identifier.scopusid | 2-s2.0-85052931799 | - |
dc.citation.number | 9 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Dolichos lablab L | - |
dc.subject.keywordAuthor | chikusetsusaponin IVa | - |
dc.subject.keywordAuthor | triterpenoid saponin | - |
dc.subject.keywordAuthor | anti-obesity | - |
dc.subject.keywordAuthor | 3T3-L1 cell differentiation | - |
dc.subject.keywordPlus | AESCULUS-TURBINATA BLUME | - |
dc.subject.keywordPlus | ACID-BINDING PROTEINS | - |
dc.subject.keywordPlus | DIET-INDUCED OBESITY | - |
dc.subject.keywordPlus | ADIPOCYTE DIFFERENTIATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | 3T3-L1 PREADIPOCYTES | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | PANCREATIC LIPASE | - |
dc.subject.keywordPlus | PLATYCODI RADIX | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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