Electronically Matching C-H Alkylation Strategies for the Synthesis of alpha-Heteroaryl Acetic Acid Derivatives
DC Field | Value | Language |
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dc.contributor.author | Jang, Ha-Lim | - |
dc.contributor.author | Kim, Hyun Tae | - |
dc.contributor.author | Cho, Eun Jin | - |
dc.contributor.author | Joo, Jung Min | - |
dc.date.available | 2019-03-08T16:01:22Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 2193-5807 | - |
dc.identifier.issn | 2193-5815 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8883 | - |
dc.description.abstract | A strategy in which complementary species are paired for the preparation of alpha-heteroaryl esters and amides from heteroarenes was developed. Readily available alpha-haloacetates and alpha-acetamides provided the requisite acetate and acetamide groups via three distinctive reactive species, namely nucleophilic carbanions, alkylpalladium complexes, and photoredox-generated electrophilic radicals. Based on their electronic properties, these intermediates were matched with various five-membered heteroarenes, such as pyrazoles, imidazoles, thiophenes, furans, pyrroles, and indoles. These flexible protocols offer easy access to alpha-heteroaryl acetic acid derivatives and expand the scope of heteroarenes that can be utilized for C-H alkylation. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Electronically Matching C-H Alkylation Strategies for the Synthesis of alpha-Heteroaryl Acetic Acid Derivatives | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ajoc.201500388 | - |
dc.identifier.bibliographicCitation | ASIAN JOURNAL OF ORGANIC CHEMISTRY, v.4, no.12, pp 1386 - 1391 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000368137500007 | - |
dc.identifier.scopusid | 2-s2.0-84955165337 | - |
dc.citation.endPage | 1391 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1386 | - |
dc.citation.title | ASIAN JOURNAL OF ORGANIC CHEMISTRY | - |
dc.citation.volume | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | C-H activation | - |
dc.subject.keywordAuthor | cross-coupling | - |
dc.subject.keywordAuthor | photocatalysis | - |
dc.subject.keywordAuthor | vicarious nucleophilic aromatic substitution | - |
dc.subject.keywordAuthor | alpha-heteroaryl acetic acid derivatives | - |
dc.subject.keywordPlus | VICARIOUS NUCLEOPHILIC-SUBSTITUTION | - |
dc.subject.keywordPlus | CATALYZED DIRECT ALKYLATION | - |
dc.subject.keywordPlus | LIGHT PHOTOREDOX CATALYSIS | - |
dc.subject.keywordPlus | CROSS-COUPLING REACTION | - |
dc.subject.keywordPlus | ARYLBORONIC ACIDS | - |
dc.subject.keywordPlus | BORONIC ACIDS | - |
dc.subject.keywordPlus | PENTATOMIC HETEROAROMATICS | - |
dc.subject.keywordPlus | C(SP(2))-H BONDS | - |
dc.subject.keywordPlus | C(SP(3))-H BONDS | - |
dc.subject.keywordPlus | DIRECT ARYLATION | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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