Nano "Chocolate Waffle" for near-IR Responsive Drug Releasing System
DC Field | Value | Language |
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dc.contributor.author | Lee, Junseok | - |
dc.contributor.author | Park, Hansoo | - |
dc.contributor.author | Kim, Won Jong | - |
dc.date.available | 2019-03-08T16:38:27Z | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.issn | 1613-6829 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/8999 | - |
dc.description.abstract | A majority of the photo-responsive drug-delivery systems that are currently being studied require a complicated synthesis method. Here, we prepare a near-infrared responsive, photothermally controllable, drug-delivery carrier by a simple mixing and extraction process without the incorporation of toxic chemicals. A blend of doxorubicin (DOX), an anticancer drug, and a phase-change material (PCM) are loaded onto the mesoporous structure of silica-coated graphene oxide (GO@MS) to form a waffle-like structure, which is confirmed by various physicochemical analyses. The cytotoxicity of DOX/PCM-loaded GO@MS (DOX/PCM-GO@MS) against HeLa cells is 50 times higher than that of free DOX, and this improved activity can be attributed to the photothermal effectiveness of GO@MS. Additionally, the cytotoxicity and uptake mechanism of the PCM-based material are analyzed by flow cytometry. Taken together, our results suggest an enormous potential for spatio-temporal control in photothermally responsive drug-delivery systems. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Nano "Chocolate Waffle" for near-IR Responsive Drug Releasing System | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/smll.201403228 | - |
dc.identifier.bibliographicCitation | SMALL, v.11, no.39, pp 5315 - 5323 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000363204500015 | - |
dc.identifier.scopusid | 2-s2.0-84944278159 | - |
dc.citation.endPage | 5323 | - |
dc.citation.number | 39 | - |
dc.citation.startPage | 5315 | - |
dc.citation.title | SMALL | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | nanostructures | - |
dc.subject.keywordAuthor | graphene oxide | - |
dc.subject.keywordAuthor | mesoporous silica | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | photothermal materials | - |
dc.subject.keywordPlus | PHASE-CHANGE MATERIALS | - |
dc.subject.keywordPlus | CELLULAR UPTAKE MECHANISM | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | GRAPHENE OXIDE | - |
dc.subject.keywordPlus | INTRACELLULAR FATE | - |
dc.subject.keywordPlus | RAMAN-SPECTROSCOPY | - |
dc.subject.keywordPlus | PARTICLE-SIZE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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