An effective strategy to prevent allopurinol-induced hypersensitivity by HLA typing
DC Field | Value | Language |
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dc.contributor.author | Jung , Jae Woo | - |
dc.contributor.author | Kim, Dong-Ki | - |
dc.contributor.author | Park, Heung-Woo | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.contributor.author | Joo, Kwon-Wook | - |
dc.contributor.author | Kim, Yon-Su | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Lee, Kyung Wha | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.contributor.author | Min, Kyung-Up | - |
dc.contributor.author | Kang, Hye-Ryun | - |
dc.date.available | 2019-03-08T16:39:18Z | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 1098-3600 | - |
dc.identifier.issn | 1530-0366 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9045 | - |
dc.description.abstract | Purpose: This study was conducted to evaluate the usefulness of human leukocyte antigen (HLA) typing in preventing allopurinol-induced severe cutaneous adverse reactions (SCARs) through the application of an allopurinol tolerance induction protocol or prescription of other alternative medications in high-risk patients. Methods: HLA typing was performed in patients with chronic renal insufficiency who needed allopurinol. HLA-B*58:01-negative patients were prescribed the usual dose of allopurinol. For HLAB*58:01-positive patients, administration of either allopurinol based on a 28-day tolerance induction protocol or alternative medications was initiated. Hypersensitivity reactions were surveyed for 90 days and compared with the result of a previous retrospective cohort study. Results: Among a total of 401 study subjects, no SCARs were noted in HLA-B*58:01-positive patients with application of the tolerance were any SCARs observed in HLA-B*58:01-negative patients who started allopurinol at the usual dose (n = 355). Compared with the previous retrospective cohort study, a significant reduction in SCARs was observed in HLA-B*58:01-positive patients (0 vs. 18%; P = 0.002). Conclusion: This study shows the usefulness of HLA-B* 58: 01 screening in identifying patients at high risk for the development of allopurinol-induced SCARs and suggests that application of a -tolerance induction protocol or alternative medications could be an effective strategy to prevent allopurinol-induced SCARs in HLAB*58:01-positive patients. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | An effective strategy to prevent allopurinol-induced hypersensitivity by HLA typing | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/gim.2014.195 | - |
dc.identifier.bibliographicCitation | GENETICS IN MEDICINE, v.17, no.10, pp 807 - 814 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000362441900009 | - |
dc.identifier.scopusid | 2-s2.0-84934946645 | - |
dc.citation.endPage | 814 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 807 | - |
dc.citation.title | GENETICS IN MEDICINE | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | allopurinol | - |
dc.subject.keywordAuthor | drug hypersensitivity | - |
dc.subject.keywordAuthor | HLA-B*58:01 antigen | - |
dc.subject.keywordAuthor | immune tolerance | - |
dc.subject.keywordAuthor | renal insufficiency, chronic | - |
dc.subject.keywordPlus | TOXIC EPIDERMAL NECROLYSIS | - |
dc.subject.keywordPlus | STEVENS-JOHNSON-SYNDROME | - |
dc.subject.keywordPlus | CUTANEOUS ADVERSE-REACTIONS | - |
dc.subject.keywordPlus | RENAL-INSUFFICIENCY | - |
dc.subject.keywordPlus | DRUG-REACTIONS | - |
dc.subject.keywordPlus | HYPERURICEMIA | - |
dc.subject.keywordPlus | ABACAVIR | - |
dc.subject.keywordPlus | GOUT | - |
dc.subject.keywordPlus | HLA-B-ASTERISK-5701 | - |
dc.subject.keywordPlus | DESENSITIZATION | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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