Multi-Compartmental Hydrogel Microparticles Fabricated by Combination of Sequential Electrospinning and Photopatterning
- Authors
- Cho, Kanghee; Lee, Hyun Jong; Han, Sang Won; Min, Ji Hong; Park, Hansoo; Koh, Won-Gun
- Issue Date
- Sep-2015
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- drug delivery; electrospun fibers; hydrogels; microparticles; photopatterning
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.54, no.39, pp 11511 - 11515
- Pages
- 5
- Journal Title
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Volume
- 54
- Number
- 39
- Start Page
- 11511
- End Page
- 11515
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9098
- DOI
- 10.1002/anie.201504317
- ISSN
- 1433-7851
1521-3773
- Abstract
- Multi-compartmental non-spherical hydrogel microparticles were fabricated by combining electrospinning and photopatterning. Sequential electrospinning produced multi-layered fiber matrices with different composition in which each layer became a compartment of the particle. Photopatterning of the hydrogel in the presence of the multilayered fiber matrix generated multi-compartmental microparticles with different vertical functionalities. While the shapes of the hydrogel microparticles were determined by the design of the photomask, the chemical properties and size of each compartment were independently controlled by changing the molecules incorporated into each fiber matrix and the electrospinning times, respectively. The resultant multi-compartmental hydrogel microparticles could carry out not only the release of different growth factors with independent kinetics but also binding of multiple targets at different compartments.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.