Comparative analysis between combination and single-agent chemotherapy for elderly patients with advanced non-small cell lung cancer: A nationwide population-based outcome study
DC Field | Value | Language |
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dc.contributor.author | Lee, Yun-Gyoo | - |
dc.contributor.author | Lee, Ju Hyun | - |
dc.contributor.author | Kim, Se-Hyun | - |
dc.contributor.author | Kim, Yu Jung | - |
dc.contributor.author | Lee, Heeyoung | - |
dc.contributor.author | Ahn, Soyeon | - |
dc.contributor.author | Jang, Joung-Soon | - |
dc.contributor.author | Lee, Jong-Seok | - |
dc.contributor.author | Kim, Jee Hyun | - |
dc.date.available | 2019-01-22T12:59:05Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.issn | 1872-8332 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/913 | - |
dc.description.abstract | Introduction: To determine whether an upfront combination compared to single-agent therapy is beneficial for elderly patients with advanced non-small cell lung cancer (NSCLC) in the real world, a population-based epidemiologic study was conducted. Methods: Patients >= 70 years with advanced NSCLC from 2007 to 2012 were identified in the National Health Insurance Service Database of Korea. A Cox proportional-hazards regression model and propensity score analysis were used to examine the effect of treatment modality on survival. Results: Among 41,276 patients newly diagnosed with lung cancer, 8274 (20.0%) identified to be treated with upfront palliative chemotherapy were eligible for this study. After excluding 976 patients who received a first line anti-epidermal growth factor receptor (EGFR) treatment, 7298 (88.2%) who received cytotoxic chemotherapy were included in further analyses: 5636 (77.2%) received doublet chemotherapy and 1662 (22.8%) received monotherapy. The most frequent regimen in combination group was gemcitabine and platinum doublet (44.7%), whereas that in monotherapy group was gemcitabine (46.7%). Multivariate analyses indicated lower use of combination chemotherapy with increasing age (odds ratio [OR] 0.73; 95% CI 0.67-0.79; P < 0.001) and female sex (OR 0.71; 95% CI 0.62-0.80; P < 0.001). Receipt of combination over single-agent chemotherapy was associated with a reduced risk of death (hazard ratio [HR] 0.91; 95% CI 0.86-0.96; P = 0.001) in overall population and (HR 0.89; 95% CI 0.80-0.98; P = 0.019) in the propensity-matched cohort. Conclusion: In elderly patients with advanced NSCLC excluding those receiving frontline anti-EGFR targeted agents, receiving initial combination chemotherapy compared to single-agent was associated with improved survival. | - |
dc.format.extent | 6 | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Comparative analysis between combination and single-agent chemotherapy for elderly patients with advanced non-small cell lung cancer: A nationwide population-based outcome study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.lungcan.2018.05.028 | - |
dc.identifier.bibliographicCitation | LUNG CANCER, v.122, pp 88 - 93 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000440769900015 | - |
dc.identifier.scopusid | 2-s2.0-85047954678 | - |
dc.citation.endPage | 93 | - |
dc.citation.startPage | 88 | - |
dc.citation.title | LUNG CANCER | - |
dc.citation.volume | 122 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Non-small cell lung cancer | - |
dc.subject.keywordAuthor | Elderly | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | Survival | - |
dc.subject.keywordPlus | OLDER PATIENTS | - |
dc.subject.keywordPlus | TRIALS | - |
dc.subject.keywordPlus | REGISTRATION | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | DATABASE | - |
dc.subject.keywordPlus | SERVICE | - |
dc.subject.keywordPlus | KOREA | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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