Individual differences in novelty-seeking behavior in spontaneously hypertensive rats: Enhanced sensitivity to the reinforcing effect of methylphenidate in the high novelty-preferring subpopulation
DC Field | Value | Language |
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dc.contributor.author | dela Pena, Ike | - |
dc.contributor.author | Gonzales, Edson Luck | - |
dc.contributor.author | de la Pena, June Bryan | - |
dc.contributor.author | Kim, Bung-Nyun | - |
dc.contributor.author | Han, Doug Hyun | - |
dc.contributor.author | Shin, Chan Young | - |
dc.contributor.author | Cheong, Jae Hoon | - |
dc.date.available | 2019-03-08T16:56:41Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 0165-0270 | - |
dc.identifier.issn | 1872-678X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9213 | - |
dc.description.abstract | Background: High novelty seeking has been assumed to predict vulnerability to use addictive drugs. Notably, it is also a symptom associated with attention-deficit/hyperactivity disorder (ADHD). The aim of this study was to identify whether spontaneously hypertensive rats (SHRs), putative animal models of ADHD, display individual differences in novelty-seeking behavior, and whether high novelty-seeking SHRs show enhanced sensitivity to the reinforcing effect of methylphenidate, the most commonly prescribed stimulant ADHD medication. Methods: First, we established that SHRs show higher levels of novelty-seeking behavior than their normotensive control strain, Wistar Kyoto (WKY) rats. Novelty seeking was measured in two tests: open field test in a novel test arena, and novel object preference tests. Thereafter, SHRs were classified into high responders (HR) or low responders (LR), high novelty-preferring (HNP) or low novelty-preferring (LNP) rats, based on individual scores in the two behavioral assays. Methylphenidate self-administration was assessed thereafter. Results: SHRs showed higher levels of novelty-seeking behavior than WKY rats. HR/LR and HNP/LNP subgroups were identified. HR and LR rats showed comparable rates of methylphenidate self-administration. However, HNP SHRs worked more for methylphenidate infusions than their LNP counterparts. Conclusions: We showed some evidence on inter-individual variations in novelty seeking in SHRs. Importantly, we demonstrated enhanced sensitivity of HNP SHRs to the reinforcing effect of methylphenidate, indicating a "drug-vulnerable" SHR subpopulation. These findings are important as they may provide basis for a potential screening tool to identify a subset of ADHD patients (i.e. high novelty seekers) who may be at risk for misusing/abusing methylphenidate. (C) 2014 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Individual differences in novelty-seeking behavior in spontaneously hypertensive rats: Enhanced sensitivity to the reinforcing effect of methylphenidate in the high novelty-preferring subpopulation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jneumeth.2014.08.019 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSCIENCE METHODS, v.252, pp 48 - 54 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000359957700006 | - |
dc.identifier.scopusid | 2-s2.0-84944708864 | - |
dc.citation.endPage | 54 | - |
dc.citation.startPage | 48 | - |
dc.citation.title | JOURNAL OF NEUROSCIENCE METHODS | - |
dc.citation.volume | 252 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | SHR | - |
dc.subject.keywordAuthor | Novelty-seeking | - |
dc.subject.keywordAuthor | Methylphenidate | - |
dc.subject.keywordAuthor | ADHD | - |
dc.subject.keywordAuthor | Addiction | - |
dc.subject.keywordPlus | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | - |
dc.subject.keywordPlus | DEFICIT HYPERACTIVITY DISORDER | - |
dc.subject.keywordPlus | CONDITIONED PLACE PREFERENCE | - |
dc.subject.keywordPlus | SUBSTANCE USE DISORDERS | - |
dc.subject.keywordPlus | EXON-III POLYMORPHISM | - |
dc.subject.keywordPlus | ANIMAL-MODEL | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | SENSATION-SEEKING | - |
dc.subject.keywordPlus | YOUNG-ADULTS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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