Inhibition of discoidin domain receptor 2-mediated lung cancer cells progression by gold nanoparticle-aptamer-assisted delivery of peptides containing transmembrane-juxtamembrane 1/2 domain
DC Field | Value | Language |
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dc.contributor.author | Kim, Daehwan | - |
dc.contributor.author | Yeom, Ji-Hyun | - |
dc.contributor.author | Lee, Boeun | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Bae, Jeehyeon | - |
dc.contributor.author | Rhee, Sangmyung | - |
dc.date.available | 2019-03-08T16:56:47Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9220 | - |
dc.description.abstract | The delivery of biologically functional peptides into mammalian cells can be a direct and effective method for cancer therapy and treatment of other diseases. Discoidin domain receptor 2 (DDR2) is a collagen-induced receptor tyrosine kinase recently identified as a novel therapeutic target in lung cancer. In this study, we report that peptides containing the functional domain of DDR2 can be efficiently delivered into lung malignant cancer cells via a gold nanoparticle-DNA aptamer conjugate (AuNP-Apt)-based system. Peptide delivery resulted in the abrogation of DDR2 activation triggered by collagen. Moreover, the peptide delivered by the AuNP-Apt system inhibited cancer cell proliferation and invasion mediated by DDR2 activation. Thus, these results suggest that peptide loaded onto AuNP-Apt conjugates can be used for the development of peptide-based biomedical applications for the treatment of DDR2-positive cancer. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Inhibition of discoidin domain receptor 2-mediated lung cancer cells progression by gold nanoparticle-aptamer-assisted delivery of peptides containing transmembrane-juxtamembrane 1/2 domain | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2015.06.044 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.464, no.2, pp 392 - 395 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000359514000005 | - |
dc.identifier.scopusid | 2-s2.0-84938423389 | - |
dc.citation.endPage | 395 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 392 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 464 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Discoidin domain receptor 2 | - |
dc.subject.keywordAuthor | Juxtamembrane domain | - |
dc.subject.keywordAuthor | DNA aptamer | - |
dc.subject.keywordAuthor | Gold nanoparticle | - |
dc.subject.keywordAuthor | Peptide delivery | - |
dc.subject.keywordPlus | TYROSINE KINASES | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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