Development of a genetic marker set to diagnose aspirin-exacerbated respiratory disease in a genome-wide association study
DC Field | Value | Language |
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dc.contributor.author | Chang, H. S. | - |
dc.contributor.author | Shin, S. W. | - |
dc.contributor.author | Lee, T. H. | - |
dc.contributor.author | Bae, D. J. | - |
dc.contributor.author | Park, J. S. | - |
dc.contributor.author | Kim, Y. H. | - |
dc.contributor.author | Uh, S. T. | - |
dc.contributor.author | Choi, B. W. | - |
dc.contributor.author | Kim, M. K. | - |
dc.contributor.author | Choi, I. S. | - |
dc.contributor.author | Park, B. L. | - |
dc.contributor.author | Shin, H. D. | - |
dc.contributor.author | Park, C. S. | - |
dc.date.available | 2019-03-08T16:58:06Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 1470-269X | - |
dc.identifier.issn | 1473-1150 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9285 | - |
dc.description.abstract | We developed a genetic marker set of single nucleotide polymorphisms (SNPs) by summing risk scores of 14 SNPs showing a significant association with aspirin-exacerbated respiratory disease (AERD) from our previous 660 W genome-wide association data. The summed scores were higher in the AERD than in the aspirin-tolerant asthma (ATA) group (P = 8.58 x 10(-37)), and were correlated with the percent decrease in forced expiratory volume in 1 s after aspirin challenge (r(2) = 0.150, P = 5.84 x 10(-30)). The area under the curve of the scores for AERD in the receiver operating characteristic curve was 0.821. The best cutoff value of the summed risk scores was 1.01328 (P = 1.38 x 10(-32)). The sensitivity and specificity of the best scores were 64.7% and 85.0%, respectively, with 42.1% positive and 93.4% negative predictive values. The summed risk score may be used as a genetic marker with good discriminative power for distinguishing AERD from ATA. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Development of a genetic marker set to diagnose aspirin-exacerbated respiratory disease in a genome-wide association study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/tpj.2014.78 | - |
dc.identifier.bibliographicCitation | PHARMACOGENOMICS JOURNAL, v.15, no.4, pp 316 - 321 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000358448500004 | - |
dc.identifier.scopusid | 2-s2.0-84937814960 | - |
dc.citation.endPage | 321 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 316 | - |
dc.citation.title | PHARMACOGENOMICS JOURNAL | - |
dc.citation.volume | 15 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | INDUCED ASTHMA | - |
dc.subject.keywordPlus | INTOLERANT ASTHMA | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.subject.keywordPlus | TOLERANT ASTHMA | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | HYPERSENSITIVITY | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | EICOSANOIDS | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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