Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, Seongil | - |
dc.contributor.author | Woo, Hae Dong | - |
dc.contributor.author | Kwon, Ho-Jang | - |
dc.contributor.author | Oh, Se-Young | - |
dc.contributor.author | Park, Jung-Duck | - |
dc.contributor.author | Hong, Young-Seoub | - |
dc.contributor.author | Pyo, Heesoo | - |
dc.contributor.author | Park, Kyung Su | - |
dc.contributor.author | Ha, Mina | - |
dc.contributor.author | Kim, Ho | - |
dc.contributor.author | Sohn, Seok-Joon | - |
dc.contributor.author | Kim, Yu-Mi | - |
dc.contributor.author | Lim, Ji-Ae | - |
dc.contributor.author | Lee, Sang-Ah | - |
dc.contributor.author | Eom, Sang-Yong | - |
dc.contributor.author | Kim, Byoung-Gwon | - |
dc.contributor.author | Lee, Kyoung-Mu | - |
dc.contributor.author | Lee, Jong-Hyeon | - |
dc.contributor.author | Hwang, Myung Sil | - |
dc.contributor.author | Kim, Jeongseon | - |
dc.date.available | 2019-03-08T16:58:29Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 1660-4601 | - |
dc.identifier.issn | 1660-4601 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9305 | - |
dc.description.abstract | Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 +/- 8.6 days. The population mean of the methylmercury half-life was 81.6 +/- 8.4 days for men and 78.9 +/- 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 +/- 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijerph120809054 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.12, no.8, pp 9054 - 9067 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000360587800028 | - |
dc.identifier.scopusid | 2-s2.0-84938535661 | - |
dc.citation.endPage | 9067 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 9054 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | biological half-life | - |
dc.subject.keywordAuthor | dietary exposure | - |
dc.subject.keywordAuthor | methylmercury | - |
dc.subject.keywordAuthor | one-compartment toxicokinetic model | - |
dc.subject.keywordAuthor | population model | - |
dc.subject.keywordPlus | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject.keywordPlus | METHYL MERCURY | - |
dc.subject.keywordPlus | FISH CONSUMPTION | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | HUMANS | - |
dc.subject.keywordPlus | HAIR | - |
dc.subject.keywordPlus | VARIABILITY | - |
dc.subject.keywordPlus | INGESTION | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.