β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Ko, Jiwon | - |
dc.contributor.author | Bao, Cheng | - |
dc.contributor.author | Park, Hyun-Chang | - |
dc.contributor.author | Kim, Minchae | - |
dc.contributor.author | Choi, Hyung-Kyoon | - |
dc.contributor.author | Kim, Young-Suk | - |
dc.contributor.author | Lee, Hong Jin | - |
dc.date.available | 2019-03-08T17:01:12Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9451 | - |
dc.description.abstract | beta-Thujaplicin, one of the major constituents in Chamaecyparis obtusa, has been demonstrated to exert different health beneficial efficacy, but the role of beta-thujaplicin in regulating mammary tumorigenesis has not been investigated. In this study, we found that beta-thujaplicin significantly suppressed the proliferation through arresting the cell cycle transition from G1 to S phase as well as inhibited the expression of cell cycle-related proteins, cyclin D1, and cyclin-dependent kinase 4 (CDK4) in MCF-7 and T47D luminal subtype breast cancer cells. In addition, estrogen receptor alpha (ER-alpha) was down-regulated by beta-thujaplicin via enhanced proteolysis by ubiquitination, which led to cell growth inhibition. These results suggest that beta-thujaplicin may be considered as a potent agent regulating the hormone sensitive mammary tumorigenesis. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/09168451.2015.1008978 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.79, no.6, pp 1011 - 1017 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000356239400021 | - |
dc.identifier.scopusid | 2-s2.0-84940093475 | - |
dc.citation.endPage | 1017 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1011 | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 79 | - |
dc.type.docType | Article | - |
dc.publisher.location | 일본 | - |
dc.subject.keywordAuthor | beta-thujaplicin | - |
dc.subject.keywordAuthor | ubiquitination | - |
dc.subject.keywordAuthor | cyclin D1 | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | estrogen receptor | - |
dc.subject.keywordPlus | TARGET GENES | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | HINOKITIOL | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ARREST | - |
dc.subject.keywordPlus | CYCLE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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