The n-Butanol Fraction and Rutin from Tartary Buckwheat Improve Cognition and Memory in an In Vivo Model of Amyloid-beta-Induced Alzheimer's Disease
DC Field | Value | Language |
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dc.contributor.author | Choi, Ji Yeon | - |
dc.contributor.author | Lee, Jeong Min | - |
dc.contributor.author | Lee, Dong Gu | - |
dc.contributor.author | Cho, Sunghun | - |
dc.contributor.author | Yoon, Young-Ho | - |
dc.contributor.author | Cho, Eun Ju | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.date.available | 2019-03-08T17:01:22Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.issn | 1557-7600 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9457 | - |
dc.description.abstract | This study examined the beneficial effects of the n-butanol fraction and rutin extracted from tartary buckwheat (TB) on learning and memory deficits in a mouse model of amyloid beta (A beta)-induced Alzheimer's disease (AD). Learning and memory were assessed using the T-maze, object recognition, and Morris water maze tests. Animals administered A beta showed impaired cognition and memory, which were alleviated by oral administration of an n-butanol fraction and rutin extracted from TB. Similarly, A beta-induced increases in nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys were attenuated by treatment with n-butanol fraction and rutin from TB in addition to antioxidant effects observed in control (nonA beta-treated) animals. The results of the present study suggest that the n-butanol fraction and rutin extracted from TB are protective against and have possible therapeutic applications for the treatment of AD. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.title | The n-Butanol Fraction and Rutin from Tartary Buckwheat Improve Cognition and Memory in an In Vivo Model of Amyloid-beta-Induced Alzheimer's Disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1089/jmf.2014.3292 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.18, no.6, pp 631 - 641 | - |
dc.identifier.kciid | ART002003509 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000360531500004 | - |
dc.identifier.scopusid | 2-s2.0-84929657108 | - |
dc.citation.endPage | 641 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 631 | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | tartary buckwheat | - |
dc.subject.keywordAuthor | rutin | - |
dc.subject.keywordAuthor | Alzheimer's disease | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | amyloid beta | - |
dc.subject.keywordAuthor | memory | - |
dc.subject.keywordPlus | THIOBARBITURIC ACID REACTION | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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