Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide
DC Field | Value | Language |
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dc.contributor.author | Back, Moon Jung | - |
dc.contributor.author | Ha, Hae Chan | - |
dc.contributor.author | Fu, Zhicheng | - |
dc.contributor.author | Choi, Jong Min | - |
dc.contributor.author | Piao, Yongwei | - |
dc.contributor.author | Won, Jong Hoon | - |
dc.contributor.author | Jang, Ji Min | - |
dc.contributor.author | Shin, In Chul | - |
dc.contributor.author | Kim, Dae Kyong | - |
dc.date.available | 2019-01-22T13:29:13Z | - |
dc.date.issued | 2018-06-04 | - |
dc.identifier.issn | 2041-4889 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/951 | - |
dc.description.abstract | Autophagy is essential for optimal cell function and survival, and the entire process accompanies membrane dynamics. Ceramides are produced by different enzymes at different cellular membrane sites and mediate differential signaling. However, it remains unclear which ceramide-producing pathways/enzymes participate in autophagy regulation under physiological conditions such as nutrient starvation, and what the underlying mechanisms are. In this study, we demonstrate that among ceramide-producing enzymes, neutral sphingomyelinase 2 (nSMase2) plays a key role in autophagy during nutrient starvation. nSMase2 was rapidly and stably activated upon starvation, and the enzymatic reaction in the Golgi apparatus facilitated autophagy through the activation of p38 MAPK and inhibition of mTOR. Moreover, nSMase2 played a protective role against cellular damage depending on autophagy. These findings suggest that nSMase2 is a novel regulator of autophagy and provide evidence that Golgi-localized ceramides participate in cytoprotective autophagy against starvation. | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41419-018-0709-4 | - |
dc.identifier.bibliographicCitation | CELL DEATH & DISEASE, v.9, no.6 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000434024500006 | - |
dc.identifier.scopusid | 2-s2.0-85048097773 | - |
dc.citation.number | 6 | - |
dc.citation.title | CELL DEATH & DISEASE | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | SQUAMOUS CARCINOMA-CELLS | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | REGULATES AUTOPHAGY | - |
dc.subject.keywordPlus | MAMMALIAN TARGET | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | HUMAN HEAD | - |
dc.subject.keywordPlus | P38 MAPK | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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