Phase II study of mFOLFOX3 (5-fluorouracil, leucovorin, oxaliplatin) as second-line treatment after gemcitabine failure in patients with unresectable/metastatic biliary tract cancer
- Authors
- Hwang, In Gyu; Jang, Joung-Soon; Oh, Sung Yong; Rho, Myung Hwan; Lee, Suee; Park, Young Suk; Park, Joon Oh; Nam, Eun Mi; Lee, Hyo Rak; Jun, Hyun Jung; Chi, Kyong-Choun
- Issue Date
- Apr-2015
- Publisher
- SPRINGER
- Keywords
- Biliary tract cancer; Second line; Fluorouracil; Oxaliplatin
- Citation
- CANCER CHEMOTHERAPY AND PHARMACOLOGY, v.75, no.4, pp 757 - 762
- Pages
- 6
- Journal Title
- CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Volume
- 75
- Number
- 4
- Start Page
- 757
- End Page
- 762
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9685
- DOI
- 10.1007/s00280-015-2691-1
- ISSN
- 0344-5704
1432-0843
- Abstract
- We conducted a phase II trial of 5-fluorouracil and oxaliplatin combination chemotherapy as a second-line treatment in unresectable/metastatic biliary tract cancer patients who had failed gemcitabine-based chemotherapy. Patients treated with gemcitabine-based palliative treatment were enrolled in this study. Patients were received modified FOLFOX3 (mFOLFOX3) consists of oxaliplatin 85 mg/m(2) (day 1) and leucovorin 30 mg (days 1, 2) followed by 5-fluorouracil 1,500 mg/m(2) (days 1, 2) every 2 weeks. Between March 2010 and June 2012, a total of 30 patients were enrolled in this study. Twenty-eight patients were measurable for treatment response. One achieved complete response, and one a partial response was observed. Overall response rate was 7.1 % (95 % confidence interval 0.9-23.5 %). The median progression-free survival was 1.6 months, and the median overall survival was 4.4 months. Grade 3-4 hematologic toxicities included neutropenia (6.7 %) and thrombocytopenia (3.4 %). The most common non-hematologic toxicity was neuropathy (22.2 %). However, the most common grade 3-4 non-hematologic toxicity was hyperbilirubinemia (5.0 %). There was one treatment-related death due to neutropenic infection. mFOLFOX3 as a second-line regimen has modest effect and tolerable toxicity in unresectable/metastatic biliary tract cancer patients who have been treated previously via gemcitabine-based chemotherapy.
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