Prestroke antiplatelet agents in first-ever ischemic stroke Clinical effects
DC Field | Value | Language |
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dc.contributor.author | Jung, Jin-Man | - |
dc.contributor.author | Choi, Jungsoon | - |
dc.contributor.author | Eun, Mi-Yeon | - |
dc.contributor.author | Seo, Woo-Keun | - |
dc.contributor.author | Cho, Kyung-Hee | - |
dc.contributor.author | Yu, Sungwook | - |
dc.contributor.author | Oh, Kyungmi | - |
dc.contributor.author | Hong, Soonwoong | - |
dc.contributor.author | Park, Kwang-Yeol | - |
dc.date.available | 2019-03-08T17:41:43Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.issn | 1526-632X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9750 | - |
dc.description.abstract | Objective:To investigate whether prestroke antiplatelet agent (PA) use was associated with initial stroke severity.Methods:This was a retrospective, case-control study based on data from a prospectively collected hospital-based stroke registry (Korea University Stroke Registry). A total of 3,025 patients who were admitted with a diagnosis of first-ever ischemic stroke within 5 days of symptom onset were included. Stroke severity was measured with the NIH Stroke Scale (NIHSS). NIHSS score 4 at admission was categorized as mild stroke. Patients from the PA group were matched with those from the non-PA group using estimated propensity scores at a 1:1 ratio. Stepwise multivariable logistic regression analyses were performed on patients in the matched datasets with initial mild stroke.Results:Patients' mean age was 66.3 13.0 years, and 1,850 were men (61.5%). A total of 748 patients had been taking antiplatelet agents prior to stroke onset; 644 patients (86.1%) were taking a single antiplatelet agent. Among these agents, aspirin (83.7%) was the most common. A total of 102 patients (13.6%) were taking 2 antiplatelet agents. Multivariable analysis after propensity score matching demonstrated that PA use was associated with initial mild stroke (odds ratio 1.344; 95% confidence interval 1.014-1.782).Conclusions:PA use was associated with decreased first-ever stroke severity, suggesting that it has a beneficial effect.Classification of evidence:This study provides Class II evidence that prestroke use of antiplatelet agents reduces stroke severity in patients with first-ever acute ischemic stroke. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Prestroke antiplatelet agents in first-ever ischemic stroke Clinical effects | - |
dc.type | Article | - |
dc.identifier.doi | 10.1212/WNL.0000000000001361 | - |
dc.identifier.bibliographicCitation | NEUROLOGY, v.84, no.11, pp 1080 - 1089 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000351458600008 | - |
dc.identifier.scopusid | 2-s2.0-84925326063 | - |
dc.citation.endPage | 1089 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1080 | - |
dc.citation.title | NEUROLOGY | - |
dc.citation.volume | 84 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | TREATMENT TOAST | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | ASPIRIN | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | STATINS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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