Pharmacological action of DA-9701 on the motility of feline stomach circular smooth muscle
DC Field | Value | Language |
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dc.contributor.author | Thanh Thao Nguyen | - |
dc.contributor.author | Song, Hyun Ju | - |
dc.contributor.author | Ko, Sung Kwon | - |
dc.contributor.author | Sohn, Uy Dong | - |
dc.date.available | 2019-03-08T17:56:33Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 0031-7144 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9798 | - |
dc.description.abstract | DA-9701, a new prokinetic agent for the treatment of functional dyspepsia, is formulated with Pharbitis semen and Corydalis tuber. This study wasconducted to determine the pharmacological action of DA-9701 and to identify the receptorsinvolved in DA-9701-induced contractile responsesin the feline gastric corporal, fundic and antral circular smooth muscle. Concentration-response curve to DA-9701 was established. The tissue trips were exposed to methylsergide, ketanserin, ondansetron, GR 113808, atropine and dopamine before administration ofDA-9701. The contractile force was determined before and after administration of drugs by a polygraph.DA-9701 enhanced the spontaneous contractile amplitude of antrum, corpus and fundus. However, it did not change the spontaneous contractile frequency of antrum and corpus, but concentration-dependently reduced that of fundus. In the fundus, DA-9701-induced tonic contractions were inhibited by dopamine, methylsergide, ketanserine, ondansetron or GA 113808 respectively, but not by atropine, indicating that the contractile responses are mediated by multiple receptors: 5-HT2, 5-HT3, 5-HT4, and dopamine receptors. In the corpus, DA-9701-induced contractions were blocked by atropine, dopamine or GR 113808, but not by methysergide, ketanserin or ondansetron, indicating that they are involved in receptors on both, smooth muscles and neurons: 5-HT4 and dopamine receptors. However, contractile responses to DA-9701 are mainly mediated by dopamine receptors in the antrum.These results suggest that DA-9701 has important roles in gastric accommodation by enhancing tonic activity of fundus, and in gastric emptying and gastrointestinal transit by phasic contractions of corpus and antrummediated by multiple receptors. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH | - |
dc.title | Pharmacological action of DA-9701 on the motility of feline stomach circular smooth muscle | - |
dc.type | Article | - |
dc.identifier.doi | 10.1691/ph.2015.4563 | - |
dc.identifier.bibliographicCitation | PHARMAZIE, v.70, no.3, pp 183 - 192 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000350536400005 | - |
dc.identifier.scopusid | 2-s2.0-84930242596 | - |
dc.citation.endPage | 192 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 183 | - |
dc.citation.title | PHARMAZIE | - |
dc.citation.volume | 70 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordPlus | GUINEA-PIG STOMACH | - |
dc.subject.keywordPlus | RECEPTORS MEDIATING CONTRACTION | - |
dc.subject.keywordPlus | GASTRIC FUNDUS TONE | - |
dc.subject.keywordPlus | INTERSTITIAL-CELLS | - |
dc.subject.keywordPlus | FUNCTIONAL DYSPEPSIA | - |
dc.subject.keywordPlus | CORYDALIS TUBER | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | SLOW WAVES | - |
dc.subject.keywordPlus | 5-HYDROXYTRYPTAMINE-RECEPTOR SUBTYPES | - |
dc.subject.keywordPlus | PROKINETIC AGENT | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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