Comparison of a three-in-one total nutrient mixture with conventional peripheral parenteral nutrition in children

Abstract

Background: The aim of this study was to compare clinical aspects of the application of three-in-one total nutrient mixture (TNA) for peripheral parenteral nutrition (PPN) with those of the conventional PPN (cPPN) method of providing short-term parenteral nutrition for pediatric inpatients. Methods: We conducted a retrospective study in children from 2 to 18 years old who were hospitalized and underwent PPN administration. We compared clinical aspects of two methods of PPN, cPPN (n=39) and TNA (n=57). Results: The mean age was 6.5 +/- 3.1 years in the cPPN group and 8.2 +/- 3.4 years in the TNA group (p=0.015). In the TNA group, there was a significantly shorter period between the day of admission and the first day of PPN or oral feeding (p<0.0001 & p<0.0001, respectively). The TNA group also fasted for a shorter period before PN after admission, and the total duration of fasting was also shorter (p<0.0001 & p<0.0001, respectively). The TNA group showed a lower glucose infusion rate and fewer daily administered total calories per weight (p<0.0001 & p=0.001, respectively). However, there was no significant difference in the amount of administered amino acids and lipids (p=0.584 & p=0.650, respectively) and PPN-related complications. Conclusions: When providing nutrients to hospitalized children who cannot take in enough nutrients via the enteral route, TNA formula may be an easier and faster method than cPPN.